Results 71 to 80 of about 841,523 (313)

A Need for Better Housing to Further reduce Indoor Malaria Transmission in Areas with High Bed Net Coverage. [PDF]

, 2013
The suppression of indoor malaria transmission requires additional interventions that complement the use of insecticide treated nets (ITNs) and indoor residual spraying (IRS).
Devine, Gregor J, Dickson W Lwetoijera, Mageni, Zawadi D, Lwetoijera, Dickson W, Harris, Caroline, Kiware, S S, Caroline Harris, Silas Majambere, Mageni, Z D, Devine, G J, Lwetoijera, Dickson, Gregor J Devine, Stefan Dongus, Dongus, Stefan, Kiware, Samson S, Samson S Kiware, Zawadi D Mageni, Majambere, Silas   +17 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Characteristics of tuberculosis contact of children with pulmonary tuberculosis [PDF]

, 2006
Background Children with tuberculosis (TB) are often asymptomatic, so that if TB is diagnosed in a child, an adult contact should be looked for. We realize the importance of TB control by breaking the chain of transmission, so identification of ...
Laila, Retno Murti, Sidhartani, Magdalena   +1 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Occupational Blood Exposures in Health Care Workers at a Tertiary Teaching Hospital: Incidence, Characteristics and Transmission of Blood Borne Pathogens

, 2020
Health care workers (HCW) are at risk of contracting Hepatitis B, Hepatitis C and Human immunodeficiency viruses through Occupational Blood Exposure (OBE).
Anitha Deva, Jebamani Hepzibai, Prabhakar Kamarthi, Beena Parvangada Madappa, Jyothi A.V.   +4 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Neural Network-Driven Transmission Characteristics Modeling and Manufacturing Error Detection for Photonic Lanterns

Photonics
Traditional numerical simulation methods struggle to accurately characterize the transmission characteristics of finished photonic lanterns that contain manufacturing errors.
Zhuruixiang Sun, Xiang Li, Yao Lu, Tong Liu, Zilun Chen, Zongfu Jiang   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Analysis of Tooth Profile Characteristics and Meshing Characteristics of Double Cycloid Needle Tooth Transmission

In order to solve the problems of the traditional output structure of the cycloid pinion transmission, such as easy damage and complex structure, a new type of cycloid pinion gear is proposed by applying the internal and external cycloid tooth profile to
Bai Guozhen, Lu Xinhao, Cui Jiankun, Zhang Deqi, Ding Jiale   +4 more
core   +1 more source