Results 31 to 40 of about 7,103,704 (238)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

It is Time to Address Airborne Transmission of COVID-19

Clinical Infectious Diseases, 2020
This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses.
L. Morawska, D. Milton
semanticscholar   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

TRANSMISSION MEASUREMENTS UNDER GLANCING-INCIDENCE CONDITIONS [PDF]

Le Journal de Physique Colloques, 1989
We present a method allowing the measurement of the transmission coefficient of a surface or a thin film for X-rays and neutrons. The geometry of the experiment is described as well as results obtained on a multilayer film deposited on a silicon substrate.
openaire   +1 more source

Macroeconomic conditions and health: Inspecting the transmission mechanism [PDF]

Economics & Human Biology, 2018
We study the relationship between macroeconomic conditions and self-reported health in a large sample of Italian individuals, focusing on the mediating role played by health behaviors (smoking, alcohol consumption, physical activity, eating habits) and economic stress. Our findings indicate that, overall, higher local unemployment is negatively related
Colombo Emilio, Rotondi Valentina, Stanca Luca   +2 more
openaire   +4 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Schrödinger Operators with Oblique Transmission Conditions in $${\mathbb R}^2$$

Communications in Mathematical Physics, 2023
AbstractIn this paper we study the spectrum of self-adjoint Schrödinger operators in $$L^2(\mathbb {R}^2)$$ L 2 ( R
Jussi Behrndt, Markus Holzmann, Georg Stenzel   +2 more
openaire   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Transmission Conditions for the Helmholtz-Equation in Perforated Domains [PDF]

Vietnam Journal of Mathematics, 2016
We study the Helmholtz equation in a perforated domain . The domain Ωε. The domain Ωε is obtained from an open set Ω⊂ℝ³ by removing small obstacles of typical size ε > 0, the obstacles are located along a 2-dimensional manifold Γ0 ⊂Ω, We derive effective transmission conditions across Γ0 that characterize solutions in the limit ε→0O. We obtain that,
Dörlemann, Christina, Heida, Martin, Schweizer, Ben   +2 more
openaire   +3 more sources

Determining Health Index of Transmission Line Asset using Condition-Based Method

Resources, 2019
Assessment of overhead transmission lines is a crucial task in the asset management of electric power infrastructures. Any assets have different life spans and require proper assessment and maintenance actions.
Ruqayyah Hashim, Fathoni Usman, I. Baharuddin   +2 more
semanticscholar   +1 more source