Results 41 to 50 of about 382,813 (266)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Effects of Wear, Backlash, and Bearing Clearance on Dynamic Characteristics of a Spur Gear System
IEEE Access, 2019 A six-degree-of-freedom gear pair torsional vibration model considering time-varying stiffness, damping, dynamic backlash, bearing radial clearance and comprehensive wear of the tooth surface is established by using the lumped mass method in this paper ...
Ying-Kui Gu +3 more
doaj +1 more source
Mechanical Engineering Journal, 2023 To improve the load characteristics of the transmission error for helical gears, a gear made of laminated materials is proposed. The gear has three layers in which metals with different rigidities are laminated in the tooth width direction. The layers on
Fumitaka YOSHIZUMI +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Explores for the source of the gears in traditional Japanese clock (Wadokei)
Nihon Kikai Gakkai ronbunshu, 2017 The purpose of this study is to understand the nature of one of the oldest gears used in traditional Japanese clock. Today's gear manufacturing technology in Japan came mostly from Europe and America, but we do not know exactly, when and how the ...
Akio UEDA +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
Applied Sciences, 2019 Transmission error is the key index for characterizing the transmission precision of precision reducers, and its accurate measurement is significant for the precision evaluation of precision reducers.
Hang Xu, Zhaoyao Shi, Bo Yu, Hui Wang
doaj +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source