Results 41 to 50 of about 70,445 (357)

Drag reduction on a transonic airfoil

Journal of Fluid Mechanics, 2022
Flow control for turbulent skin-friction drag reduction is applied to a transonic airfoil to improve its aerodynamic performance. The study is based on direct numerical simulations (with up to 1.8 billion cells) of the compressible turbulent flow around a supercritical airfoil, at Reynolds and Mach numbers of $Re_\infty = 3 \times 10^{5}$
Maurizio Quadrio, Alessandro Chiarini, Jacopo Banchetti, Davide Gatti, Antonio Memmolo, Sergio Pirozzoli   +5 more
openaire   +4 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Off-Design Aerodynamics of the SPLEEN C1 Cascade

International Journal of Turbomachinery, Propulsion and Power
High-speed, low-pressure turbines in geared turbofans operate at transonic exit Mach numbers and low Reynolds numbers. Engine-relevant data remain scarce.
Gustavo Lopes, Loris Simonassi, Antonino Federico Maria Torre, Marios Patinios, Sergio Lavagnoli   +4 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Manifold Learning for Aerodynamic Shape Design Optimization

Aerospace
The significant computational cost incurred due to the iterative nature of Computational Fluid Dynamics (CFD) in traditional aerodynamic shape design frameworks poses a major challenge, especially in the context of modern integrated design requirements ...
Boda Zheng, Abhijith Moni, Weigang Yao, Min Xu   +3 more
doaj   +1 more source

Study of separation phenomenon in transonic flows produced by interaction between shock wave and boundary layer

Vietnam Journal of Mechanics, 2011
For compressible flows, the transonic state depends on the geometry, Mach number and the incidence. This effect can produce shock wave. Some studies showed that the interaction between shock wave and boundary layer concerns separation phenomenon. Studies
Hoang Thi Bich Ngoc, Nguyen Manh Hung
doaj   +1 more source

Global Solutions of Viscous Transonic Flows in Kerr Geometry I: Weak Viscosity Limit [PDF]

, 1996
We present fully general relativistic equations governing viscous transonic flows in vertical equilibrium in Kerr geometry. We find the complete set of global solutions (both for Optically thick and optically thin flows) in the weak viscosity limit.
Chakrabarti, Sandip K.
core   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Sensitivity analysis and multi-objective robust design optimization of compact aero-engine nacelles

Engineering Applications of Computational Fluid Mechanics
Future civil aero-engines are expected to feature larger bypass ratios and fan diameters to reduce specific thrust and improve propulsive efficiency, thereby lowering specific fuel consumption. These new configurations introduce design challenges, as the
Guocheng Tao, Yang Liu, Zhouteng Ye, Chengwei Fan, Yanzhao Gong, Yan Yan, Jiahuan Cui   +6 more
doaj   +1 more source