Results 61 to 70 of about 70,445 (357)

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Stability of Transonic Shock Solutions for One-Dimensional Euler-Poisson Equations

, 2010
In this paper, both structural and dynamical stabilities of steady transonic shock solutions for one-dimensional Euler-Poission system are investigated.
B. Zhang, C.V. Pao, Chunjing Xie, D. Wang, D.P. Chen, F. Huang, G.-Q. Chen, G.Q. Chen, H. Li, I.M. Gamba, I.M. Gamba, J. Li, J. Li, J. Rauch, J. Rauch, J. Rauch, Jeffrey Rauch, M.D. Rosini, M.D. Rosini, P. Degond, P. Degond, P. Embid, P.A. Markowich, P.A. Markowich, S.-Y. Ha, S.-Y. Ha, T. Luo, T.P. Liu, T.P. Liu, T.P. Liu, Tao Luo, U.M. Ascher, W.-C. Lien, Y.-J. Peng, Z. Xin, Z. Xin, Zhouping Xin   +36 more
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Hysteresis effects and diagnostics of the shock formation in low angular momentum axisymmetric accretion in the Kerr metric

, 2009
The secular evolution of the purely general relativistic low angular momentum accretion flow around a spinning black hole is shown to exhibit hysteresis effects.
Abraham, Abramowicz, Abramowicz, Abramowicz, Abramowicz, Abramowicz, Afshordi, Anderson, Armitage, Artemova, B. Czerny, Balbus, Barai, Beloborodov, Beskin, Bhattacharjee, Bhattacharjee, Bisikalo, Bondi, Boyer, Bray, Bussemaker, Caditz, Campbell, Chakrabarti, Chakrabarti, Chakrabarti, Chattopadhyay, Chaudhury, Chen, Chicone, Czerny, Das, Das, Das, Das, Das, Das, Das, Frank, Fukue, Fukue, Fukue, Fukue, Fukumura, Goswami, Hawley, Ho, Igumenshchev, Igumenshchev, Illarionov, Illarionov, Janiuk, Jordan, Kafatos, Kaplan, Karkowski, Karkowski, Kato, Kato, Konigl, Landau, Liang, Liang, Lu, Lu, Lu, Lu, MacFadyen, Manmoto, Matsumoto, Moscibrodzka, Muchotrzeb, Muchotrzeb, Muchotrzeb-Czerny, Mukhopadhyay, Nagakura, Nagakura, Nakayama, Nakayama, Narayan, Novikov, Okuda, Okuda, Paczyński, Paczyński, Pariev, Parker, Peitz, Pringle, Proga, Ray, Ray, Ray, Ray, Ray, Ray, Ryu, Sakurai, Shakura, Sponholz, Spruit, Takahashi, Tapas K. Das, Tóth, Wiita, Yang   +106 more
core   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Design considerations of the national transonic facility [PDF]

The inability of existing wind tunnels to provide aerodynamic test data at transonic speeds and flight Reynolds numbers was examined. The proposed transonic facility is a high Reynolds number transonic wind tunnel designed to meet the research and ...
Baals, D. D.
core   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Prediction of effects of wing contour modifications on low-speed maximum lift and transonic performance for the EA-6B aircraft [PDF]

Computational predictions of the effects of wing contour modifications on maximum lift and transonic performance were made and verified against low speed and transonic wind tunnel data.
Allison, Dennis O., Waggoner, E. G.
core   +1 more source

Radial transonic shock solutions of Euler-Poisson system in convergent nozzles

, 2017
Given constant data of density $\rho_0$, velocity $-u_0{\bf e}_r$, pressure $p_0$ and electric force $-E_0{\bf e}_r$ for supersonic flow at the entrance, and constant pressure $p_{\rm ex}$ for subsonic flow at the exit, we prove that Euler-Poisson system
Bae, Myoungjean, Park, Yong
core   +1 more source