Results 31 to 40 of about 47,947 (362)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The role of flow geometry in influencing the stability criteria for low angular momentum axisymmetric black hole accretion

, 2010
Using mathematical formalism borrowed from dynamical systems theory, a complete analytical investigation of the critical behaviour of the stationary flow configuration for the low angular momentum axisymmetric black hole accretion provides valuable ...
Abraham, Abramowicz, Abramowicz, Abramowicz, Afshordi, Aretemova, Arnab K. Ray, Balbus, Barai, Bardeen, Beloborodov, Beskin, Beskin, Beskin, Bhattacharjee, Bhattacharjee, Bisikalo, Blaes, Bohr, Caditz, Chakrabarti, Chakrabarti, Chakrabarti, Chandrasekhar, Chandrasekhar, Chaudhury, Das, Das, Das, Das, Das, Davis, Demianski, Eardley, Fragile, Frank, Fukue, Fukue, Fukue, Fukue, Fukumura, Fukumura, Goswami, Gu, Gu, Ho, Hubeny, Igumenshchev, Igumenshchev, Illarionov, Illarionov, Jordan, Kafatos, Kato, Kumar, Lense, Liang, Liang, Lu, Lu, Lu, Lu, Lu, Lynden-Bell, Maccarone, Mandal, Matsumoto, Muchotrzeb, Muchotrzeb, Muchotrzeb-Czerny, Nagakura, Nagakura, Nakayama, Nakayama, Narayan, Nelson, Nowak, Paczyński, Petterson, Petterson, Piran, Pringle, Proga, Ray, Ray, Ray, Ray, Ray, Sankhasubhra Nag, Scheuer, Shakura, Shakura, Swagata Acharya, Takahashi, Takahashi, Tapas K. Das, Theuns, Tóth, Visser, Yang   +99 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Study of Separation Control of Vortex Generators on Transonic Wings

Journal of Fluid Science and Technology, 2011
Flows around vortex generators (VGs), which serve as one of the important flow control methods, are investigated by solving Reynolds-Averaged Navier-Stokes (RANS) equations. The influences on the main flow of VGs are intended to explore.
Jingbo HUANG, Song FU, Zhixiang XIAO, Miao ZHANG   +3 more
doaj   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

A Modified Fifth-Order WENO-HLLC Riemann Solver for Transonic Viscous Flows around Helicopter Rotor in Hover

Shock and Vibration, 2022
This paper presents a modified fifth-order WENO-HLLC Riemann solver for the transonic compressible viscous flows around the helicopter rotor in hover. The HLLC approximate Riemann solver is proposed to discrete the convection term involving grid velocity
Li Xu, Fengfeng Zhao, Jingjing Cai
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Accurate 2-D Modelling of Transonic Compressor Cascade Aerodynamics

Aerospace, 2019
Modern aeronautic fans are characterised by a transonic flow regime near the blade tip. Transonic cascades enable higher pressure ratios by a complex system of shockwaves arising across the blade passage, which has to be correctly reproduced in order to ...
Tommaso Piovesan, Andrea Magrini, Ernesto Benini   +2 more
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

On the challenge of five-hole-probe measurements at high subsonic Mach numbers in the wake of transonic turbine cascades

Journal of the Global Power and Propulsion Society, 2018
Five-hole-probes are common use in turbomachinery flow investigations, even though, inserting a probe into a flow field inevitably induces perturbations to the flow which can falsify the measurement results, especially when exposed to transonic flows ...
Marcel Boerner, Martin Bitter, Reinhard Niehuis   +2 more
doaj   +1 more source