Results 41 to 50 of about 41,355 (316)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Numerical analysis of transonic flow over the FFA-W3-211 wind turbine tip airfoil [PDF]

Wind Energy Science
Modern wind turbines are the largest rotating machines ever built, with blade lengths exceeding 100 m. Previous studies demonstrated how the flow around the tip airfoils of such large machines reaches local flow Mach numbers (Ma), at which the ...
M. C. Vitulano, M. C. Vitulano, D. De Tavernier, G. De Stefano, D. von Terzi   +4 more
doaj   +1 more source

Critical properties of spherically symmetric accretion in a fractal medium

, 2007
Spherically symmetric transonic accretion of a fractal medium has been studied in both the stationary and the dynamic regimes. The stationary transonic solution is greatly sensitive to infinitesimal deviations in the outer boundary condition, but the ...
Abramowicz, Afshordi, Arnab K. Ray, Artemova, Axford, Babichev, Balazs, Barabási, Begelman, Blumenthal, Bohr, Bonazzola, Bonazzola, Bondi, Brinkmann, Burkert, Chakrabarti, Chakrabarti, Chandrasekhar, Chaudhury, Choudhuri, Cowie, Crovisier, Das, Das, Das, Das, Debnath, Elmegreen, Faison, Falgarone, Frank, Gaite, Garlick, Goswami, Heithausen, Hill, Jordan, Kazhdan, Klessen, Kovalenko, Langer, Larson, Malec, Mandal, Mandelbrot, Markovic, Matsumoto, Michel, Moncrief, Muchotrzeb-Czerny, Mészáros, Mészáros, Nirupam Roy, Nowak, Paczyński, Parker, Parker, Petterson, Ray, Ray, Ray, Ren, Roy, Semelin, Shu, Stellingwerf, Strogatz, Tarasov, Theuns, Titarchuk, Titarchuk, Toropin, Tsuribe, Visser, Vitello, Zampieri, Zaslavsky   +77 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

The transonic safe mode as an enabler of next-generation wind turbines

Communications Engineering
The wind energy industry is moving towards larger and more powerful turbines, with next-generation designs expected to operate at blade tip speeds exceeding 100 m s −1.
Delphine A. M. De Tavernier, Michiel B. Zaaijer, Dominic A. von Terzi   +2 more
doaj   +1 more source

Transonic flow field in critical flow Venturi nozzle

Applied and Computational Mechanics
In this paper, theoretical and numerical analysis of a transonic flow field of critical flow Venturi nozzles according to the ISO 9300 standard is performed. Deviations of the flow field from an estimate based on one dimensionality are clarified.
Kreuzová T.
doaj   +1 more source

Harnessing Fungal Biowelding for Constructing Mycelium‐Engineered Materials

Advanced Engineering Materials, EarlyView.
Mycelium‐bound composites (MBCs) offer low‐carbon alternatives for construction, yet interfacial bonding remains a critical challenge. This review examines fungal biowelding as a biocompatible adhesive, elucidating mycelium‐mediated interfacial mechanisms and their role in material assembly. Strategies to optimize biowelding are discussed, highlighting
Xue Brenda Bai, Xinrui Sarah Niu, Zhao Qin   +2 more
wiley   +1 more source

Zein‐Based Adhesives: Sustainable Extraction and Application in Bioadhesive Technologies

Advanced Engineering Materials, EarlyView.
Zein is extracted from corn gluten meal using a simple and scalable process with high yield (~90%). The resulting protein is applied in bioadhesives modified with Ca2+ and Fe3+ ions, exhibiting substrate‐dependent adhesion. The findings demonstrate competitive bonding performance and highlight the role of ionic interactions in tuning adhesion ...
Paula Bertolino Sanvezzo, Daniela Winsley Valereto Friozi, Vinícius de Oliveira, Marcia Cristina Branciforti   +3 more
wiley   +1 more source

The performance of proper orthogonal decomposition in discontinuous flows

Theoretical and Applied Mechanics Letters, 2016
In this paper, flow reconstruction accuracy and flow prediction capability of discontinuous transonic flow field by means of proper orthogonal decomposition (POD) method is studied. Although linear superposition of “high frequency waves” in different POD
Jing Li, Weiwei Zhang
doaj   +1 more source