Results 61 to 70 of about 1,709,361 (350)

Transparent and non-transparent languages [PDF]

Folia Linguistica, 2018
Abstract Languages differ widely from one another in the extent to which they are transparent, i.e. obey one-to-one relationships between meaning and form. Transparency, in turn, is an important factor in the learnability of languages. This paper first sets out a framework for the study of transparency and subsequently studies cross-linguistic ...
Hengeveld, K., Leufkens, S.
openaire   +5 more sources

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Comparison of treatment effect sizes from pivotal and postapproval trials of novel therapeutics approved by the FDA based on surrogate markers of disease: a meta-epidemiological study

BMC Medicine, 2018
Background The U.S. Food and Drug Administration (FDA) often approves new drugs based on trials that use surrogate markers for endpoints, which involve certain trade-offs and may risk making erroneous inferences about the medical product’s actual ...
Joshua D. Wallach, Oriana Ciani, Alison M. Pease, Gregg S. Gonsalves, Harlan M. Krumholz, Rod S. Taylor, Joseph S. Ross   +6 more
doaj   +1 more source

State capture through indemnification demands? Effects on equity in the global distribution of COVID-19 vaccines

Journal of Pharmaceutical Policy and Practice, 2022
Background State capture by the pharmaceutical industry is a form of corruption whereby pharmaceutical companies shift laws or policies about their products away from the best interest of the public and toward their private benefit.
Ariel Gorodensky, Jillian C. Kohler
doaj   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

CURBING LAND CORRUPTION AN AFRICAN PREREQUISITE FOR FREE TRADE

African Journal on Land Policy and Geospatial Sciences
The existence, survival and continuity of a number of income-generating activities (farming, mining, etc.) depend on land, making it an important lever for a country's development.
Lovaniaina Mirella RANDRIAMALALA
doaj   +1 more source

Low Incidence of Relapses After Vaccination in Anti‐Aquaporin‐4 Antibody‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Patients with neuromyelitis optica spectrum disorder (NMOSD) may experience increased signs and symptoms of their underlying disease when vaccinated against meningococcal disease before receiving complement component 5 inhibitor therapies. This retrospective analysis indicated an overall low relapse incidence (mean [range], 3.3% [0.7%–10.6 ...
Sean J. Pittock, Jin Nakahara, Becky Parks, Kerstin Allen, Sami Fam   +4 more
wiley   +1 more source

Systematic overview of Freedom of Information Act requests to the Department of Health and Human Services from 2008 to 2017

Research Integrity and Peer Review, 2019
Background The Freedom of Information Act (FOIA) provides access to unreleased government records that can be used to enhance the transparency and integrity of biomedical research. We characterized FOIA requests to Department of Health and Human Services
Alexander C. Egilman, Joshua D. Wallach, Christopher J. Morten, Peter Lurie, Joseph S. Ross   +4 more
doaj   +1 more source

Von Economo Neuron Loss in Frontotemporal Dementia: A Meta‐Analysis of Neuropathological Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Von Economo neurons (VENs) have been reported to be vulnerable to neurodegeneration in frontotemporal dementia (FTD), particularly the behavioral variant (bvFTD), but these findings have not been systematically assessed across independent brain banks.
Daniel Talmasov, Alexander F. Santillo, Patrick R. Hof   +2 more
wiley   +1 more source

Clinical trial transparency at McGill University

McGill Journal of Medicine, 2020
Transparency in clinical trials is an issue under considerable scrutiny at present, and rightfully so, given that people's lives are both used as a resource in such research and affected by its results.
Richeek Pradhan, Olivia Bonardi
doaj