Results 41 to 50 of about 4,223 (112)

Sailing Through Time: Building Pacific Maritime Resilience

Global Policy, EarlyView.
ABSTRACT This article examines the Pacific Blue Shipping Partnership (PBSP), an ambitious initiative aimed at decarbonising maritime transport across Oceania. The study explores the cultural, historical and technological aspects of wind‐propelled shipping in the Pacific.
Christiaan De Beukelaer, John Taukäve, Maria Sahib, Eldine Glees, Aseri Driu, Joshua Lakabung, Atina Schutz, Joseph H. Genz, Shania G. Tamagyongfal, Jerolynn K. Myazoe, Alexander Mawyer, Alson Kelen, Larry Raigetal, Raffael Held, Andrew Irvin, Morgan Wairiu, Peter Nuttall, Transform Aqorau, Kyrie Lalauvaki, Aileen Sefeti, John Kautoke   +20 more
wiley   +1 more source

Differential segment‐specific signalling pathways for guanylate cyclase C‐activated anion secretion in murine ileocolon

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu, Johannes Reiner, Franz Hofmann, Azam Salari, Ursula Seidler   +4 more
wiley   +1 more source

Genetic dissection reveals distinct contributions of the eS31 N‐terminal domain to translational accuracy in Saccharomyces cerevisiae

The FEBS Journal, EarlyView.
The eukaryote‐specific N‐terminal domain (NTD) of eS31 uses two distinct strategies to maintain translation fidelity. During elongation, a positively charged “hotspot” fine‐tunes the selection of incoming aa‐tRNA. During termination, the entire NTD acts as a structural scaffold to ensure the correct positioning of the release factor eRF1.
Qingxuan Gao, Hiroshi Otsuka, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Arabidopsis inositol polyphosphate kinase activities regulate COP9 deneddylation functions in phosphate homeostasis

Journal of Integrative Plant Biology, EarlyView.
Plant phosphate (Pi) homeostasis relies on coordinated activities of the inositol polyphosphate kinases IPK1 and ITPK1, which balance localized InsP7 biosynthesis to control COP9 signalosome (CSN)‐dependent deneddylation of cullin 1 (CUL1). Perturbation of this equilibrium affects the stability of SPX4, a key negative regulator of phosphate starvation ...
Yashika Walia, Medha Noopur, Ishana Bhattacharya, Bhaskar Chandra Sahoo, Mritunjay Kasera, Naga Jyothi Pullagurla, Smritikana Dutta, Guizhen Liu, Gabriel Schaaf, Henning Jessen, Debabrata Laha, Souvik Bhattacharjee, Saikat Bhattacharjee   +12 more
wiley   +1 more source

Understanding public perspectives of prehospital trauma research: A qualitative community engagement study on consent and blood transfusion

Transfusion, EarlyView.
Abstract Background Unintentional injuries are a major cause of death worldwide. Modern trauma systems have reduced morbidity and mortality through rapid prehospital care, yet trauma research faces challenges obtaining informed consent during emergencies.
Katie N. Dainty, M. Bianca Seaton, Krystle Amog, Melissa McGowan, Brodie Nolan, on behalf of the SWiFT Canada Investigators, Yulia Lin, Michael Peddle, Jeannie Callum, Andrew Beckett, Luis Da Luz, Ian Drennan, Katerina Pavenski, Johnathan Mack, Mahvareh Ahghari, Jason E Smith, Laura Green, Connie Colaveccchia1, Harley Meirovich, Amie Malkin, Paul Engels, Michelle Zeller, Courtney Mullen, Leah Hayward, Andrew Shih, Sebastien Vuong, Kelly Vogt, Ziad Solh, Laura Allen, Jeff Kinney, Christopher Evans, Aiden Scholey, Jason Prpic, Marvin Jones, Julia Philion, Jonathan Briton, Geoffrey Brown, Jason Crockett, Mark Gravely, Charles Keown‐Stoneman   +39 more
wiley   +1 more source

Prospective in silico trials identify combined SK and K2P channel block as an effective strategy for atrial fibrillation cardioversion

The Journal of Physiology, EarlyView.
Abstract figure legend In silico trials were conducted in 654 virtual patients with atrial fibrillation (AF) to assess the cardioversion efficacy of three pharmacological treatments: single SK and K2P channel block and combined SK+K2P channel inhibition. Left: representative virtual AF patient with the atria inside the torso.
Albert Dasí, Lucas Arantes Berg, Hector Martinez‐Navarro, Alfonso Bueno‐Orovio, Blanca Rodriguez   +4 more
wiley   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Sensitivity of Risk‐Based Demand Curves to Analytical Fragility Function Fitting Using Multiple‐Stripe Analyses

Earthquake Engineering &Structural Dynamics, Volume 55, Issue 9, Page 2121-2128, 25 July 2026.
ABSTRACT Risk‐based seismic assessments using demand curves that provide mean annual exceedance rates for various system demand levels are increasingly being adopted. Such assessments combine the seismic hazard curve with fragility functions for each demand level, serving as a basis to quantify the average annual losses from system damage. Constructing
Zeyad Khalil, Peter J. Stafford, Ahmed Y. Elghazouli   +2 more
wiley   +1 more source

miR‐19a‐3p and miR‐19b‐3p Promote Microglia Activation Associated With Neuroinflammation

Journal of Neuroscience Research, Volume 104, Issue 7, July 2026.
miR19a and miR19b enhance microglia activation. ABSTRACT Neuroinflammation, driven by microglia activation and the production of pro‐inflammatory cytokines, has been implicated in several neurological diseases and neuropathic pain. MicroRNAs (miRNAs) have emerged as important regulators of neuroinflammatory processes.
Faezeh Sahebdel, Ricardo A. Battaglino, Leslie R. Morse, Julie K. Olson   +3 more
wiley   +1 more source

Crataegus oxyacantha Extract Enhances Cardiac Adaptation and Reduces Oxidative‐Inflammatory Stress in Broiler Chickens Raised at High Altitude Under Cold Stress

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
Crataegus oxyacantha extract at 0.4 mL/L improved cardiac function in broilers under cold stress and high altitude by increasing nitric oxide synthase gene expression, boosting nitric oxide, reducing endothelin‐1 gene expression, and lowering oxidative‐inflammatory stress, offering a natural solution to mitigate pulmonary hypertension syndrome ...
Behnam Ahmadipour, Hossein Hassanpour, Samira Abaszadeh, Majid Kalantar   +3 more
wiley   +1 more source