Results 61 to 70 of about 548,791 (262)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Syngeneic transplantation in multiple myeloma - a case-matched comparison with autologous and allogeneic transplantation. European Group for Blood and Marrow Transplantation

, 1999
Twenty-five patients with multiple myeloma received bone marrow grafts (n = 24) or peripheral blood stem cells (n = 1) from twin donors. The outcome was compared in a case-matched analysis to 125 patients who underwent autologous transplantation, and 125
Svensson, H, Gratwohl, A, Carlson, K, Gratecos, N, Apperley, J, Gahrton, G,, Cavo, M, Fouillard, L, Björkstrand, B, Ferrant, A   +9 more
core   +1 more source

First-line tandem high-dose chemotherapy and autologous stem cell transplantation versus single high-dose chemotherapy and autologous stem cell transplantation in multiple myeloma, a systematic review of controlled studies [PDF]

, 2012
Several clinical studies have compared single with tandem (also called double) autologous stem cell transplantation (ASCT) as first-line treatment in patients with symptomatic multiple myeloma (MM), one of the leading indications for ASCT ...
Borchmann, Peter, Bohlius, Julia, Naumann-Winter, Frauke, Greb, Alexander, Engert, Andreas, Schnell, Roland   +5 more
core   +2 more sources

New autoimmune diseases after autologous hematopoietic stem cell transplantation for multiple sclerosis

, 2021
Secondary autoimmune diseases (2ndADs), most frequently autoimmune cytopenias (AICs), were first described after allogeneic hematopoietic stem cell transplantation (HSCT) undertaken for malignant and hematological indications, occurred at a prevalence of
Muraro, Paolo A, Fedorenko, Denis, Muraro, Paolo A.,, Farge, Dominique, Quigley, Kathleen,, Frasca, Daniela,, Fedorenko, Denis,, Oliveira, Maria Carolina, Burman, Joachim, Bueno, Valquiria, Saccardi, Riccardo, Quigley, Kathleen, Burman, Joachim,, Farge, Dominique,, Bueno, Valquiria,, Frasca, Daniela, Burt, Richard K, Han, Xiaoqiang, Saccardi, Riccardo,, Oliveira, Maria Carolina,, Snowden, John A.,, Han, Xiaoqiang,, Burt, Richard K.,, Snowden, John A   +23 more
core   +1 more source

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

Advanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv, Lei Zhang, Fei Fei, Zhibin Wu, Xiuquan Wu, Ya‐nan Dou, Yihao Fu, Hao Chang, Yujie Qiang, Huaxia Xie, Ni An, Leiying Chen, Hongchen Zhang, Min‐Wen Zheng, Hongqing Chen, Xia Li, Zhou Fei   +16 more
wiley   +1 more source

Autologous gastrointestinal reconstructive surgery: complement or alternative to intestinal transplantation

, 2013
PURPOSE OF REVIEW: Autologous intestinal reconstructive surgery has evolved over the past 3 decades from rescue to main surgical procedure in the multidisciplinary approach to short bowel syndrome (SBS) patients with intestinal failure.
Reding, Raymond, Fusaro, Fabio, Hermans, Dominique   +2 more
core   +1 more source

Autologous transplantation for diffuse aggressive Non-Hodgkin lymphoma in first relapse or second remission [PDF]

, 2004
We evaluated the results of high-dose chemotherapy and autologous hematopoietic stem cell transplantation in patients with diffuse aggressive non-Hodgkin lymphoma (NHL) in first relapse (Rel 1) or second complete remission (CR 2).
Loberiza, Fausto R, Lazarus, Hillard M, van Biesen, Koen, Giralt, Sergio A, McCarthy, Philip L, Nimer, Stephen D, Gibson, John, Schenkein, David P, Wiley, Joseph M, Wiernik, Peter H, Vose, Julie M, Bashey, Asad, Gale, Robert Peter, Petersen, Finn B, Rizzo, Douglas J, Armitage, James O, Herzig, Roger H, Horowitz, Mary M, Freytes, Cesar O, Tao-Wu, Jing, McCarthy, Jr, Philip L, Burns, Linda J, Lemaistre, Charles F, Christiansen, Neal Paul   +23 more
core   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

Autologous stem cell transplantation improves quality of life in economically challenged, brazilian multiple myeloma patients

Clinics, 2011
OBJECTIVES: 1) To characterize the impact of multiple myeloma on the quality of life of patients treated in two public institutions in São Paulo State, Brazil, using a generic Short Form 36 Health Survey and a questionnaire specific for oncologic ...
Leina Y Etto, Vânia Maris Morel, Vanderleia C Silva, Vania T. M Hungria, Rozana M Ciconelli, Manuella S. S Almeida, José Salvador R. de Oliveira, José Carlos Barros, Brian G Durie, Gisele W. B Colleoni   +9 more
doaj   +1 more source