Results 61 to 70 of about 75,819 (315)

Inhibitory effect of rapamycin-deep eutectic solvent eye drops on corneal allograft rejection in mice and its mechanism [PDF]

精准医学杂志
Objective To investigate the inhibitory effect of rapamycin (RAPA)-deep eutectic solvent (DES) eye drops on corneal allograft rejection in mice and its mechanism.
YANG Yang, HUANG Cixin, ZENG Fanxing, SUN Yaru, WEI Chao, WANG Hongwei, GAO Hua
doaj   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Fresh osteochondral knee allografts in Brazil with a minimum two-year follow-up

Revista Brasileira de Ortopedia
OBJECTIVE: The present study aimed to report the results of the first series of cases of fresh ostechondral allografts in the knee joint in Brazil with a minimum follow-up of two years.
Luís Eduardo Passarelli Tírico, Marco Kawamura Demange, Luiz Augusto Ubirajara Santos, José Ricardo Pécora, Alberto Tesconi Croci, Gilberto Luís Camanho   +5 more
doaj   +1 more source

Histopathologic alterations associated with the transplanted homologous dog liver [PDF]

, 1962
Homotransplanted livers in dogs developed mononuclear, lymphocytic and plasmacytic infiltration and hepatic cell degeneration roughly paralleling survival time.
Bjornboe, Dempster, Donald R. Brock, Hume, Kojima, Kukral, Mannick, Medawar, Moore, Simonsen, Starzl, Starzl, Starzl, Starzl, Thomas E. Starzl   +14 more
core   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Construction of an Insertion Vector for Gene Targeting of Chicken Lens-specific Gene

The Journal of Poultry Science, 2010
Production of gene-targeted chickens is considered to be valuable for studies in both biological science and industry, but it is yet to be achieved. In this study, an insertion vector for gene targeting of chicken lens-specific gene, delta1-crystallin ...
Yuji Fukushima, Masaharu Sato, Haruo Matsuda, Shuichi Furusawa, Hiroyuki Horiuchi   +4 more
doaj   +1 more source

Arteriography during ex vivo renal perfusion A complication [PDF]

, 1973
A case of bilateral renal-cell carcinoma unsuccessfully treated with bench surgery is reported. The reason for failure was apparently the toxicity of the contrast media used during the ex vivo arteriographic studies ...
Alfidi, Ausman, Belzer, Calne, Chaplin, D. Gallot, D.P. Stables, Hardy, J. Taubman, J.L. Corman, Knoefel, Kutt, Kutt, M. Fiala, Merserau, O. Stonington, R. Girard, Rand, Starzl, T.E. Starzl, Zinner   +20 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources