Results 71 to 80 of about 77,491 (296)
Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis
Advanced Science, EarlyView.Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu +13 more
wiley +1 more source
Thoracic duct drainage before and after cadaveric kidney transplantation [PDF]
, 1979 Twenty-seven consecutive recipients of cadaveric kidneys, including five with pre-existing warm cytotoxic antibodies, were treated with thoracic duct drainage before and after transplantation.
Iwaki, Y +5 more
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Free ureteral replacement in rats: regeneration of ureteral wall components in the acellular matrix graft. [PDF]
, 1997 ObjectivesTo evaluate ureteral replacement by a free homologous graft of acellular matrix in a rat model.MethodsIn 30 male Sprague-Dawley rats, a 0.3 to 0.8-cm midsegment of the left ureter was resected and replaced with an acellular matrix graft of ...
Dahiya, R +5 more
core +1 more source
Трансплантология (Москва), 2019 Correspondence to: Sergey P. Glyantsev, Prof., Dr. Med. Sci., Head of the Department of the History of Cardiovascular Surgery at A.N. Bakoulev National Medical Research Center for Cardiovascular Surgery, Head of the Medical History Unit within the ...
S. P. Glyantsev
doaj +1 more source
Biomedical cell product model for preclinical studies carried out on a large laboratory animal
Вестник трансплантологии и искусственных органов, 2020 Objective: to develop a model of a biomedical cell product that is consistent with the «homologous drug» strategy based on protocols for preparing the cell component and scaffold carrier for preclinical studies on a large laboratory animal (pig ...
M. N. Egorikhina +8 more
doaj +1 more source
Advanced Science, EarlyView.This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong +15 more
wiley +1 more source
ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment
Advanced Science, EarlyView.ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song +12 more
wiley +1 more source
Bladder acellular matrix graft: in vivo functional properties of the regenerated rat bladder. [PDF]
, 1999 The purpose of this study was to determine whether the rat urinary bladder augmented by an acellular matrix graft can restore the bladder's low-pressure reservoir function and preserve normal micturition.
Dahiya, R +6 more
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Advanced Science, EarlyView.Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang +12 more
wiley +1 more source
Animals bearing malignant grafts reject normal grafts that express through gene transfer the same antigen. [PDF]
, 1990 Breaking the state of immunological unresponsiveness of tumor-bearing individuals to cancer is a prerequisite for active or passive tumor-specific immunotherapy.
Koeppen, H +5 more
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