Results 71 to 80 of about 522,676 (212)

How small is too small? A systematic review of center volume and outcome after cardiac transplantation [PDF]

, 2012
Background—The aim of this study was to assess the relationship between the volume of cardiac transplantation procedures performed in a center and the outcome after cardiac transplantation.
Hawkins, N.M., Petrie, M.C., Pettit, S.J., McMurray, J.J.V., Haj-Yahia, S., Gardner, R.S., Jhund, P.S.   +6 more
core   +1 more source

BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer

Advanced Science, EarlyView.
BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu, Kangkang Liu, Keruo Wang, Heyang Guan, Jiaming Fan, Taipeng Li, Jiaru Hao, Zeyuan Wang, Yongchao Yan, Jiatong Chen, Yuan Ma, Yang Yang, Yuanjie Niu   +12 more
wiley   +1 more source

Autologous and homologous transplantation of bovine spermatogonial stem cells

, 2003
The aim of this study was to develop a method for spermatogonial stem cell transplantation into the bovine testis. Five-month-old Holstein-Friesian calves were used and half of the calves were hemicastrated to allow autologous transplantation and the ...
Kal, H.B., Oldenbroek, J.K., Woelders, H., Ouden, K., den, Coret, J., Spoormakers, T.J., Colenbrander, B., Ploeg, K., van der, Rooij, D.G., de, Lankveld, D.P., Stout, T.A.E., Stout, J.E., Izadyar, F.   +12 more
core   +2 more sources

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

Advanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu, Lu Lu, Haibo Xia, Qizhan Liu   +12 more
wiley   +1 more source

Construction of an Insertion Vector for Gene Targeting of Chicken Lens-specific Gene

The Journal of Poultry Science, 2010
Production of gene-targeted chickens is considered to be valuable for studies in both biological science and industry, but it is yet to be achieved. In this study, an insertion vector for gene targeting of chicken lens-specific gene, delta1-crystallin ...
Yuji Fukushima, Masaharu Sato, Haruo Matsuda, Shuichi Furusawa, Hiroyuki Horiuchi   +4 more
doaj   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Enxertia de pele em oncologia cutânea Skin grafts in cutaneous oncology

Anais Brasileiros de Dermatologia, 2006
Em oncologia cutânea depara-se freqüentemente com situações em que a confecção de um enxerto é uma boa alternativa para o fechamento do defeito cirúrgico.
José Anselmo Lofêgo Filho, Paula Dadalti, Diogo Cotrim de Souza, Paulo Roberto Cotrim de Souza, Marcos Aurélio Leiros da Silva, Cristina Maeda Takiya   +5 more
doaj   +1 more source

Anesthesia and Critical Care for the Prediction and Prevention for Small-for-size Syndrome: Guidelines from the ILTS-iLDLT-LTSI Consensus Conference

, 2023
BACKGROUND: During the perioperative period of living donor liver transplantation, anesthesiologists and intensivists may encounter patients in receipt of small grafts that puts them at risk of developing small for size syndrome (SFSS).
Egawa, H., Humar, A., Clavien, Pierre-Alain, Rammohan, Ashwin, Shah, Samir, Ascher, N., Clavien, P. A., Lerut, Jan, Rajakumar, A., Cattral, M., Sun, L. Y., Saigal, S., Clemens Broering, D., Kumar, Lakshmi, Clemens Broering, Dieter, Chen, Chao-Long, Bezinover, Dmitri, Findlay, J., Yi, Nam-Joon, Yoon, U., Spiro, Michael, Egawa, Hiroto, Patel, D., Yi, N. J., Kumar, L., Agarwal, Shaleen, Patel, Dhupal, Sun, Li-Ying, Humar, Abhinav, Singh, Shweta, Bhangui, P., Rajakumar, Akila, Yoon, Uzung, Kumaran, Vinay, Lerut, J., Rammohan, A., Shingina, Alexandra, Shingina, A., Bhangui, Prashant, Singh, S., Berlakovich, G., Emond, J., Chadha, Ryan, Zhu, Z. J., Saigal, Sanjiv, Chen, C. L., Rela, M., Rodriguez-Davalos, M., Sakai, Tetsuro, Bezinover, D., Shah, S., Emond, Jean, Agarwal, S., Chadha, R., Ascher, Nancy, Bhangui, Pooja, Berlakovich, Gabriela, Rodriguez-Davalos, Manuel, Rela, Mohamed, Spiro, M., Zhu, Zhi-Jun, Cattral, Mark, Sakai, T., Berenguer, M., Findlay, James, Kumaran, V., Berenguer, Marina   +66 more
core   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source