Results 41 to 50 of about 2,222,436 (336)

Highly purified and functionally stable in vitro expanded allospecific Tr1 cells expressing immunosuppressive graft-homing receptors as new candidates for cell therapy in solid organ transplantation

Frontiers in Immunology, 2023
The development of new strategies based on the use of Tr1 cells has taken relevance to induce long-term tolerance, especially in the context of allogeneic stem cell transplantation.
Saúl Arteaga-Cruz, Arimelek Cortés-Hernández, Arimelek Cortés-Hernández, Evelyn Katy Alvarez-Salazar, Evelyn Katy Alvarez-Salazar, Katya Rosas-Cortina, Christian Aguilera-Sandoval, Luis E. Morales-Buenrostro, Josefina M. Alberú-Gómez, Gloria Soldevila, Gloria Soldevila   +10 more
doaj   +1 more source

THE TRANSPLANTATION OF BONE [PDF]

BMJ, 1918
During recent years the science of bone transplantation has been occupying the attention of orthopedic surgeons to a steadily increasing degree. While the earlier operations were pure experiments attended by success or failure, depending on whether the surgeon chanced to employ the principles that are essential to success, the mass of evidence now at ...
W. E. Gallie, D. E. Robertson
openaire   +6 more sources

Impact of Donor Obesity on Outcomes After Orthotopic Heart Transplantation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background The impact of donor obesity on the outcome of orthotopic heart transplantation has not been studied. The aim of this study was to investigate the impact of donor obesity on the outcomes of adult orthotopic heart transplantation recipients ...
Yasuhiro Shudo, Jeffrey E. Cohen, Bharathi Lingala, Hao He, Y. Joseph Woo   +4 more
doaj   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

A review of transthyretin cardiac amyloidosis

Romanian Journal of Internal Medicine, 2023
Transthyretin cardiac amyloidosis is a progressive disease known to cause heart failure, conduction anomalies, and arrythmias. Due to poor outcomes and mortality from severe cardiomyopathy, prevalence and incident rates are often underreported. As global
Jhawar Nikita, Moreno Juan Carlos Leoni, Chirila Razvan   +2 more
doaj   +1 more source

Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors

Cell Reports, 2021
Summary: Age-related macular degeneration and other macular diseases result in the loss of light-sensing cone photoreceptors, causing irreversible sight impairment.
Joana Ribeiro, Christopher A. Procyk, Emma L. West, Michelle O’Hara-Wright, Monica F. Martins, Majid Moshtagh Khorasani, Aura Hare, Mark Basche, Milan Fernando, Debbie Goh, Neeraj Jumbo, Matteo Rizzi, Kate Powell, Menahil Tariq, Michel Michaelides, James W.B. Bainbridge, Alexander J. Smith, Rachael A. Pearson, Anai Gonzalez-Cordero, Robin R. Ali   +19 more
doaj   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Emergence of Blastoschizomyces capitatus Yeast Infections, Central Europe

Emerging Infectious Diseases, 2012
We report 5 cases of disseminated infection caused by Blastoschizomyces capitatus yeast in central Switzerland. The emergence of this yeast in an area in which it is not known to be endemic should alert clinicians caring for immunocompromised patients ...
Tanja Birrenbach, Sonja Bertschy, Franziska Aebersold, Nicolas J. Mueller, Yvonne Achermann, Konrad Muehlethaler, Stefan Zimmerli   +6 more
doaj   +1 more source

Infection in Organ Transplantation

American Journal of Transplantation, 2017
The prevention, diagnosis, and management of infectious disease in transplantation are major contributors to improved outcomes in organ transplantation. The risk of serious infections in organ recipients is determined by interactions between the patient ...
J. Fishman
semanticscholar   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source