Results 261 to 270 of about 18,682 (303)

The mythological chimera and new era of relapse prediction post-transplant

Blood Reviews, 2023
Allogeneic hemopoietic stem cell transplantation is the treatment of choice for high-risk or relapsed acute leukemia. However, unfortunately, relapse post-transplant continues to be the most common cause of treatment failure with 20-80% of patients relapsing based on disease risk and status at transplant.
Stefan O, Ciurea, Ashish, Kothari, Sean, Sana, Monzr M, Al Malki   +3 more
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Specification of neurepithelium and surface epithelium in avian transplantation chimeras

Development, 1991
ABSTRACT Previous studies of the avian blastoderm have revealed that extensive displacements occur within the epiblast during gastrulation and neurulation. The present study had two main purposes: (1) to map the origin and movement of prospective surface epithelial cells, and (2) to ask whether neurepithelial and surface epithelial cell ...
G C, Schoenwolf, I S, Alvarez
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Hematopoietic Stem Cell Transplantation in Utero Produces Sheep–Goat Chimeras

Blood Cells, Molecules, and Diseases, 2001
Both allogeneic and xenogeneic hematopoietic chimera models have been developed, including fetal sheep models that demonstrated high levels of stable, multilineage engraftment created by in utero hematopoietic stem cell transplantation. The aim of this study was to test the efficacy of in utero transplantation to create xenogeneic sheep-goat ...
S M, Oppenheim, M O, Muench, A, Gutiérrez-Adán, A L, Moyer, R H, BonDurant, J D, Rowe, G B, Anderson   +6 more
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Transplantation Models in Human/Mouse Chimeras

1998
We have developed novel transplantation models in human/mouse chimeras in order to study human immune responses to endothelial cells in vivo. The models consist of either human or pig skin or artery grafts placed in immunodeficient mice which are subsequently reconstituted with human mononuclear leukocytes.
G. Tellides, N. C. Kirkiles, D. A. Tereb, J. S. Schechner, J. H. Wilson, M. I. Lorber, J. S. Pober   +6 more
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Adoptive immunotherapy in canine mixed chimeras after nonmyeloablative hematopoietic cell transplantation

Blood, 2000
AbstractDevelopment of nontoxic and nonmyeloablative regimens for allogeneic hematopoietic stem-cell transplantation will decrease transplantation-related mortality caused by regimen-related toxic effects. In pursuit of this goal, a dog model of stable mixed hematopoietic chimerism was established in which leukocyte-antigen–identical litter mates are ...
GEORGES GE, STORB R., THOMPSON JD, YU C., GOOLEY T., BRUNO, Benedetto, NASH RA   +6 more
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Antibody Synthesis by Transplanted Heterologous Chimera Spleen Cells in Irradiated Recipients

The Journal of Immunology, 1961
Summary Lethally irradiated mice treated with heterologous rat bone marrow (950-r RBM chimeras) were either splenectomized or sacrificed for spleens at various intervals after treatment. Injection of these chimera spleen cells into lethally irradiated recipients resulted in the production of antibody to rat RBC antigen detectable in the ...
Gengozian, N, Carter, R, Peterson, W J
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Production of germ‐line chimeras in rainbow trout by blastomere transplantation

Molecular Reproduction and Development, 2001
AbstractWe describe a technique for producing germ‐line chimeric rainbow trout, Oncorhynchus mykiss, by microinjection of the isolated blastomeres. FITC‐labeled donor cells and non‐labeled recipient embryos at various developmental stages between the early blastula and early gastrula stages were used for cell transplantation. The chimera formation rate
Y, Takeuchi, G, Yoshizaki, T, Takeuchi
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Single cell transplantation reveals interspecific cell communication in Drosophila chimeras

Development, 1990
Abstract Cell –cell communication is not only a common strategy for cell fate specification in vertebrates, but plays important roles in invertebrate development as well. We report here on experiments testing the compatibility of mechanisms specifying cell fate among six different Drosophila species.
T, Becker, G M, Technau
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Allogeneic Haematopoietic Stem Cell Transplantation (HSCT) in Recipients of Liver Transplantation (LT)– An Orchestration Of Immune Chimera

Indian Journal of Hematology and Blood Transfusion
Vimal Kumar, Fnb
exaly   +2 more sources

Price of precaution of human-pig chimeras for transplantation purposes

Journal of Medical Ethics, 2019
In response to Koplin and Wilkinson, I argue, first, that the uncertain clinical prospects of human-pig chimera based transplantation makes the reason to spend resources for clarifying whether such practice might imply serious ethical breach due to enhanced cognitive capacities of the chimeras rather weak.
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