Results 191 to 200 of about 40,457 (265)

A Fentanyl‐Responsive Microneedle Patch for Harm Reduction

Advanced Science, EarlyView.
A fentanyl‐responsive microneedle patch is developed as a self‐regulating overdose intervention that releases naloxone upon detecting fentanyl. The system employs aptamer‐functionalized nanoparticles embedded in a swellable polymer matrix to enable rapid, on‐demand drug delivery through the skin.
Penghui Zhao, Zerui Zhou, Tyler Wolter, Huanqing Niu, Yuanzhi Bian, Chixia Tian, Chun Xu, Chenming Zhang, Juhong Chen, Matthew W. Buczynski, Wujin Sun   +10 more
wiley   +1 more source

Haploidentical transplantation with post-transplant cyclophosphamide is not inferior to 9/10-MUD transplantation with ATG in patients with myeloid malignancies. [PDF]

Bone Marrow Transplant
Gantner A, Labuhn S, Fürst D, Mannes S, Flossdorf S, Ayuk FA, Schroeder T, Stelljes M, Zeiser R, Dreger P, Eder M, Blau IW, Schetelig J, Brecht A, Burchert A, Edinger M, Wais V, Schrezenmeier H, Döhner H, Schmeller S, Fleischhauer K, Kröger N, Sala E, German Registry for Hematopoietic Stem Cell Transplantation and cell Therapy, DRST.   +24 more
europepmc   +1 more source

Synchronization‐Dissipation in the Cardiorespiratory System

Advanced Science, EarlyView.
By modeling central nervous coupling and viscoelastic interactions in the cardiorespiratory system we show that synchronization produces a 10% gain in cardiac efficiency in humans. It is surmised that respiratory sinus arrhythmia improves cardiac pumping efficiency by reducing dynamic stress and power dissipation in the pulmonary vasculature.
Joshua R. Border, Alain Nogaret, Andrew Lefevre, Vishal Jain   +3 more
wiley   +1 more source

Reticular Dysgenesis in an Extremely Low Birth Weight Infant: A Case Report. [PDF]

J Clin Immunol
Kinoshita K, Muramatsu H, Wakamatsu M, Ueda K, Sato Y, Takahashi Y.   +5 more
europepmc   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Preclinical and clinical studies on kidney allograft tolerance via hematopoietic chimerism. [PDF]

Am J Transplant
Wilson A, Souffrant A, Hansen B, Cosimi AB, Sachs DH, Kawai T.   +5 more
europepmc   +1 more source

Tumor‐Infiltrating mregDCs Restrain Anti‐Tumor Immunity in Early Relapse HCC

Advanced Science, EarlyView.
Tumor‐infiltrating mregDCs are regulated by the TNFR2‐non‐canonical NF‐κB axis, which is mediated by TNF‐α secreted by CD161+CD8+ T cells. These mregDCs recruit CD161+CD8+ T cells via the CCL20‐CCR6 axis, forming a positive feedback loop that enhances immunosuppression, promotes early recurrence of HCC, and further confirms TNFR2 as a key therapeutic ...
Zefan Zhang, Lin Ding, Yu Zhong, Haokang Feng, Linglong Huang, Waidong Huang, Chunqing Wang, Arne Östman, Beili Wang, Jian Zhou, Jia Fan, Wei Guo, Liang Wu, Yunfan Sun   +13 more
wiley   +1 more source

Systematic review of hematopoietic stem cell transplantation in patients with ataxia telangiectasia: a case report and an individual patient-level analysis. [PDF]

Front Immunol
Bekis Bozkurt H, Spaccamela VM, Hassan M, Felber M, Zeilhofer U, Zeckanovic A, Bourquin JP, Jacquier D, Ceppi F, Candotti F, Güngör T.   +10 more
europepmc   +1 more source

Mastication‐Induced Electrical Stimulation Activates Prg4+ Chondroprogenitors for Osteoarthritis Therapy

Advanced Science, EarlyView.
This study presents a ″trash‐to‐treasure″ strategy that converts harmful joint overloads into beneficial electrical cues. The biodegradable MagPie, by providing piezoelectrical stimulation and releasing Mg2+ during mastication, exerts synergistic pro‐regenerative and anti‐inflammatory effects on Prg4+ cells via the ECM‐mediated FAK‐PI3K‐Akt axis ...
Shi‐Yang Feng, Jing‐Rong Cheng, Yu Qin, Jie Lei, Chen‐Chen Gao, Hong‐Ying Fu, Li‐Ping Wu, Thanh D. Nguyen, Xu‐Liang Deng, Kai‐Yuan Fu, Yang Liu   +10 more
wiley   +1 more source

Yes, we can omit TBI for ALL! [PDF]

Blood Adv
Boelens JJ, Dvorak CC.
europepmc   +1 more source