Results 251 to 260 of about 655,517 (311)

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source

Reinterpreting the matched-sibling relapse penalty in ATG-based allogeneic transplantation for myelodysplastic neoplasms: a question of dose, not donor. [PDF]

Ann Hematol
AlJohani NI.
europepmc   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Blood urea nitrogen-to-albumin ratio predicts mortality in acute graft-versus- host disease after allogeneic stem cell transplantation. [PDF]

Front Immunol
Li G, Zhang D, Li M, Wang Y, Yuan F, Zhou J, Fu Y.   +6 more
europepmc   +1 more source

T-cell replete haploidentical transplantation compared to mismatched unrelated allogeneic transplantation with post-transplantation cyclophosphamide in patients with secondary acute myeloid leukemia in first complete remission: A study from the ALWP/EBMT. [PDF]

Bone Marrow Transplant
Kayser S, Nagler A, Ferhat AT, Sanz J, Devillier R, Koc Y, Raiola AM, Busca A, Kulagin A, Vydra J, Itala-Remes M, Bramanti S, Grillo G, Gulbas Z, Pavlu J, Rovira M, Sica S, Rambaldi A, Brissot E, Bazarbachi A, Mohty M, Ciceri F.   +21 more
europepmc   +1 more source

Treosulfan-Based Conditioning in Allogeneic Stem Cell Transplantation for Myelofibrosis: A Systematic Review. [PDF]

J Clin Med
Nasiri A, Nagiub EM, Aljurf M, Saleh MFM.   +3 more
europepmc   +1 more source

Radioimmunotherapy as a targeted strategy of reduced-intensity conditioning for allogeneic transplantation in leukemia. [PDF]

Front Oncol
Vo PT, Orozco JJ, Sandmaier BM.
europepmc   +1 more source

Improving engraftment in autologous hematopoietic stem cell transplantation: comparing pegfilgrastim with filgrastim in an outpatient setting. [PDF]

Hematol Transfus Cell Ther
Gutierrez-Aguirre CH, la Garza-Salazar F, Gómez-Almaguer D, Jaime-Pérez JC, Mancias-Guerra MDC, León AG, Colunga-Pedraza P, Mata MJM, Rosales VDCE, Catú-Rodríguez OG.   +9 more
europepmc   +1 more source

Sinusoidal obstruction syndrome in children with B-acute lymphoblastic leukemia (B-ALL) treated with inotuzumab ozogamicin: Results from the ITCC-059 trial. [PDF]

Hemasphere
Iannicelli A, Locatelli F, Jiang Y, Ammerlaan A, Rives S, van der Sluis IM, Lindemans C, Bielorai B, Díaz de Heredia C, Lissat A, Rossig C, Petit A, Rialland Battisti F, Rizzari C, Nilsson AB, Bruno B, Rubio San Simón A, Sramkova L, Engstler G, Dirksen U, Brethon B, De Moerloose B, Pasquet M, McCarthy P, Nysom K, Halfon-Domenech C, Bertorello N, Buechner J, Bader P, Zwaan CM, Brivio E.   +30 more
europepmc   +1 more source