Results 171 to 180 of about 3,354,548 (316)

Phenylalanine Versus Tyrosine (Pos. 367/332 in MCT1/MCT4) in the Substrate Binding Site Defines Affinity and Preferred Directionality of Human Monocarboxylate Transporters 1-4. [PDF]

Acta Physiol (Oxf)
Menzel M, Dumitru ID, Peters J, Hövener JB, Pravdivtsev AN, Bondar AN, Beitz E.   +6 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

GPR182 and the reframing of lacteal chylomicron uptake. [PDF]

J Clin Invest
Yu L.
europepmc   +1 more source

'Farm to Table': Air Transport Issues for an Island State

, 2013
Traditionally, a combination of heavy industry and forestry has bolstered the island state of Tasmania's economy. However, over the past two decades, the state's economic structure has seen the decline of these and the growth of industries in tourism and
Bates, Paul, Murray, Patrick, Kille, Tarryn   +2 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Axonal Transport Failure as a Cellular Mechanism of Diabetic Neuropathy. [PDF]

Cells
Kordas B, Juranek JK.
europepmc   +1 more source

Data standards for the New Zealand transport network

, 2017
As transport network operations become more and more time critical the requirement for knowledge of the performance and state of the network becomes more significant for decision support.
Miska, Marc
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Characterization of blood-brain barrier L-arginine uptake using in situ brain perfusions in a female mouse model. [PDF]

Fluids Barriers CNS
Milam OC, Wolford CP, Pecar GL, Applegate JJ, Casto ME, Gabriele DJ, Nestor AS, Lockman PR.   +7 more
europepmc   +1 more source

Quantifying transport energy efficiency savings

, 2011
The importance of quantifying energy savings and improvement in energy efficiency for each sector of the economy is now widely recognized in order to demonstrate progress towards targets and compliance with legal obligations. The focus of this paper is
Howley, Martin, Ó Gallachóir, Brian P., Dennehy, Emer J.   +2 more
core