Results 51 to 60 of about 61,913 (296)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Performance-based transit-oriented development typology

, 2010
Development of a Performance-Based TOD Typology ToolTransit-Oriented Development is a community development model that when successfully implemented can produce significant economic, environmental and social benefits for people and the neighborhoods ...
Center for Transit-Oriented Development
core   +2 more sources

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Structural transition in Bcl-xL and its potential association with mitochondrial calcium ion transport [PDF]

Scientific Reports, 2015
AbstractBcl-2 family proteins are key regulators for cellular homeostasis in response to apoptotic stimuli. Bcl-xL, an antiapoptotic Bcl-2 family member, undergoes conformational transitions, which leads to two conformational states: the cytoplasmic and membrane-bound.
Rajan, Sreekanth, Choi, Minjoo, Nguyen, Quoc Toan, Ye, Hong, Liu, Wei, Toh, Hui Ting, Kang, CongBao, Kamariah, Neelagandan, Li, Chi, Huang, Huiya, White, Carl, Baek, Kwanghee, Grüber, Gerhard, Yoon, Ho Sup   +13 more
openaire   +4 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Analysis of Kazakhstan’s transport industry in modern conditions

Halyk̦aralyk̦ k̦atynastar ža̋ne halyk̦aralyk̦ k̦u̇k̦yk̦ seriâsì, 2018
In the circumstances of the modern world countries that are located far from the main world mar- kets and don’t have access to the sea, as well as countries that are not open for cooperation in the field of world transport relations, are destined to ...
А. Мырзахметова
doaj  

EAEU Transport Policy and Single Transport Space

Путеводитель предпринимателя, 2020
In 2014, the Eurasian Economic Union was created. The states of the Eurasian Economic Union have a unique geographical and geo-economic position, high transit potential.
A. M. Novozhilov
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Transport and transit potential of the Arctic and China: problems, opportunities and prospects

Bulletin of L.N. Gumilyov Eurasian National University. Political Science. Regional Studies. Oriental Studies. Turkology Series
The Arctic region, with its changing climate and shrinking sea ice, has significant potential for transport and transit activities, especially for countries looking for new trade routes and resource exploration opportunities. This article examines the transport and transit potential of the Arctic and its significance for China.
A.B. Dauylbayev, R.S. Yelmurzayeva, T.A. Kamaljanova   +2 more
openaire   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source