Results 111 to 120 of about 7,021,795 (251)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Engineering Vanderbilt; Vol. 49 No. 01, 2008
, 2008 Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of EngineeringSchool of ...
Vanderbilt University. School of Engineering
core
Tourism facilitation as part of transport policy: Summary of international experiences. A joint ITF-OECD study [PDF]
, 2015 With over one billion international tourist arrivals per year, forecast to rise to 1.5 billion per year by 2020, transport is an essential component of the tourism system. Transport connects tourism generating regions (both domestic and international) to
OECD / International Transport Forum (Paris)
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Engineering Vanderbilt; Vol. 48 No. 02, 2007
, 2007 Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of EngineeringSchool of ...
Vanderbilt University. School of Engineering
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Engineering Vanderbilt; Vol. 52, No. 02, 2011
, 2011 Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of Engineering.Vanderbilt University.
Vanderbilt University. School of Engineering
core
International Congress of Automotive and Transport Engineering
, 2017 The volume will include selected and reviewed papers from CONAT - International Congress of Automotive and Transport Engineering to be held in Brasov, Romania, in October 2016.
Chiru, Anghel, Ispas, Nicolae
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source