Results 121 to 130 of about 492,514 (296)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Advanced mobility and transport engineering

, 2012
International audienceMultimodal transport network customers need to be directed during their travels. A travel support tool can be offered by a Multimodal Information System (MIS), which allows them to input their needs and provides them with the ...
Ksouri, Mekki, Ksouri, M., Hammadi, S., Hammadi, Slim   +3 more
core  

International Civil and Infrastructure Engineering Conference 2013

, 2014
The special focus of this proceedings is to cover the areas of infrastructure engineering and sustainability management. The state-of-the art information in infrastructure and sustainable issues in engineering covers earthquake, bioremediation ...
Hassan, Rohana, Amin, Norliyati, Fadzil, Mohd, Ismail, Zulhabri, Yusoff, Marina   +4 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

3rd International Civil and Infrastructure Engineering Conference

, 2016
The special focus of these proceedings is on the areas of infrastructure engineering and sustainability management. They provide detailed information on innovative research developments in construction materials and structures, in addition to a ...
Arshad, Mohd, Arshad, Ahmad, Awang, Haryati, Hamid, Nor, Ridzuan, Ahmad, Yusoff, Marina   +5 more
core   +1 more source

Modeling and Simulation in Transportation Engineering [PDF]

Mathematical Problems in Engineering, 2013
Wuhong Wang, Klaus Bengler, Geert Wets, Huimin Niu   +3 more
openaire   +2 more sources

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The Biophysics of Lymphatic Transport: Engineering Tools and Immunological Consequences. [PDF]

iScience, 2019
O'Melia MJ, Lund AW, Thomas SN.
europepmc   +1 more source

Performance variability: black and white or shades of grey?

, 2013
Road transport is a complex sociotechnical system prone to performance variability. Unfortunately, performance variability of road users is not well understood and methods do not provide sufficient means to provide understanding and manage performance ...
Stanton, Neville A., Stanton, N A, Salmon, P M, Salmon, Paul, Cornelissen, Miranda, McClure, Roderick, Cornelissen, M   +6 more
core