Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Charge carrier injection and transport engineering in two-dimensional transition metal dichalcogenides. [PDF]
Chem Sci, 2018 Durán Retamal JR +4 more
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Analysis of forming of students’ professional communication elements on the base of transporting and civil - engineering university according to the requests of potential employers [PDF]
, 2017 Olga Solnyshkova, Inna Makarikhina
openalex +1 more source
Infrastructure, technology and financial engineering in the transport services market
, 2022 Ardak Nurpeisova +4 more
openalex +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Band-gap engineering and ballistic transport in edge-corrugated graphene nanoribbons [PDF]
, 2009 S. Ihnatsenka +2 more
openalex +1 more source
Annual technical report, fiscal year 1979. Volume 1: Executive summary [PDF]
Accomplishments of the Point-Focusing Distributed Receiver Technology project are presented. The following aspects of the project are discussed: information dissemination, concentrator development, receiver and heat transport network development, power ...
Lucas, J. W.
core +1 more source