Results 171 to 180 of about 38,520 (261)

Study on optimization of multimodal transportation path of Jiamusi grain considering cargo loss under low carbon policy. [PDF]

Sci Rep
Ma C, Kang W, Zhou M, Liu Y, Feng J, Wang X.   +5 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Modelling the association between psychosocial work factors and risky driving: mediating roles of burnout and engagement. [PDF]

Front Public Health
Amoadu M, Ansah EW.
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

The new wave of ocean industrialization and the challenges for biodiversity conservation in the Mediterranean Sea: the case of the Costa Brava. [PDF]

Sci Rep
Lloret J, Wawrzynkowski P, Sardá R, Rigall R, Mujal-Colilles A.   +4 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

The dual impact of tobacco spending: crowding out essentials and crowding in addictive behaviors. [PDF]

Sci Rep
Merkaj E, Imami D, Drope J.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The private solution trap in collective action problems across 34 nations. [PDF]

Proc Natl Acad Sci U S A
Malthouse E, Pilgrim C, Sgroi D, Accerenzi M, Alfonso A, Ashraf RU, Baard M, Banerjee S, Belianin A, Bhattacharjee S, Bhattacharya M, Brañas-Garza P, Cárdenas JC, Carriquiry M, Choi S, Clochard GJ, Denzon EE, Dessoulavy-Sliwinski B, Dini G, Dong L, Ertl A, Exadaktylos F, Filiz-Ozbay E, Flecke SL, Galeotti F, Garcia-Muñoz T, Hanaki N, Hollard G, Horn D, Huang L, İriş D, Kiss HJ, Koch J, Kovářík J, Kwarteng OKB, Lange A, Leites M, Leung TH, Lim W, Morren M, Nockur L, Okyere CY, Oudah M, Ozkes AI, Page L, Park J, Pfattheicher S, Proestakis A, Ramos C, Ramos-Sosa M, Ashraf MS, Sanjaya MR, Schwaiger R, Sene O, Song F, Spycher S, Staněk R, Tanchingco N, Tavoni A, Te Velde V, Vázquez-De Francisco MJ, Visser M, Wang JT, Wang W, Weng WC, Werner K, Wijayanti A, Winkler R, Wooders J, Ying L, Zhen W, Hills T.   +71 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source