Results 201 to 210 of about 66,320 (342)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

IoT-Based System for Real-Time Monitoring and AI-Driven Energy Consumption Prediction in Fresh Fruit and Vegetable Transportation. [PDF]

open access: yesSensors (Basel)
Kamyod C   +11 more
europepmc   +1 more source

Multimodal transport of goods: regulatory issues

open access: yes, 2018
Tyrime yra atliekama multimodalinių krovinių vežimų, kaip teisės instituto, jiems taikytino teisinio reguliavimo ir dėl esamo teisinio reglamentavimo (jo turinio) kylančios problematikos analizė. Tyrime didelis dėmesys skiriamas tarptautinių vienarūšių krovinių vežimo konvencijų taikymo sričiai, analizuojama jų tiesioginio taikymo multimodalinio ...
openaire   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

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