Results 41 to 50 of about 101,571 (211)
Advances in Astronomy, 2013 The cosmic rays differential intensity inside the heliosphere, for energy below 30 GeV/nuc, depends on solar activity and interplanetary magnetic field polarity.
P. Bobik +11 more
doaj +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Low Mach and Peclet number limit for a model of stellar tachocline and upper radiative zones
Electronic Journal of Differential Equations, 2016 We study a hydrodynamical model describing the motion of internal stellar layers based on compressible Navier-Stokes-Fourier-Poisson system. We suppose that the medium is electrically charged, we include energy exchanges through radiative transfer and
Donatella Donatelli +3 more
doaj
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Why Do Chromospheric Oscillations in Sunspot Umbrae Appear to Propagate Downward?
The Astrophysical Journal Letters, 2023 Umbral oscillations constitute the most noticeable chromospheric feature of sunspot umbrae—large-amplitude oscillations of intensity (umbral flashes, if very strong) and line-of-sight velocity, with periods of about 3 minutes.
Jongchul Chae +6 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
PhotonicsDirect detection (DD) is a straightforward, cost-effective receiving scheme for medium- and short-range fiber-optic communication systems, yet directly accessing phase information presents inherent challenges. The temporal transport-of-intensity equation
Yue Liu +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source