Results 61 to 70 of about 101,571 (211)

Macroscopic laser–plasma interaction under strong non-local transport conditions for coupled matter and radiation

open access: yesMatter and Radiation at Extremes, 2018
Reliable simulations of laser–target interaction on the macroscopic scale are burdened by the fact that the energy transport is very often non-local. This means that the mean-free-path of the transported species is larger than the local gradient scale ...
J. Nikl   +5 more
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

open access: yesFEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

Estimation of Radon Flux Density Changes in Temporal Vicinity of the Shipunskoe Earthquake with Mw = 7.0, 17 August 2024 with the Use of the Hereditary Mathematical Model

open access: yesGeosciences
Using the data of radon accumulation in a chamber with excess volume at one of the points of the Kamchatka subsurface gas-monitoring network, the change in radon flux density due to seismic waves and post-seismic relaxation of the medium is shown.
Dmitrii Tverdyi   +2 more
doaj   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

Evaluation of Eddy Viscosity Models in Predicting Free- Stream Turbulence Penetration

open access: yesJournal of Applied Fluid Mechanics, 2013
Turbulence schemes have long been developed and examined for their accuracy and stability in a variety of environments. While many industrial flows are highly turbulent, models have rarely been tested to explore whether their accuracy withstands such ...
M. Kahrom, A Shokrgozar
doaj  

Retrogressive erosion induced by sand excavation on a riverbed

open access: yesShui kexue jinzhan, 2016
For understanding the issue of retrogressive erosion induced by excessive sand excavation on riverbed, including the influential factors, migration and prediction method, this paper provides a numerical model which is based on a set of equations ...
QI Meilan, LIU Xi, LI Jinzhao
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

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