Results 171 to 180 of about 4,232,368 (304)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Modelling Cascading Failure in Complex CPSS to Inform Resilient Mission Assurance: An Intelligent Transport System Case Study. [PDF]

Entropy (Basel)
Sobb T, Turnbull B.
europepmc   +1 more source

Application of Sensors for Incorrect Behavior Identification in a Transport System. [PDF]

Sensors (Basel), 2023
Mantič M, Kuľka J, Grega R, Virostko M, Kopas M.   +4 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Stability analysis of the incompressible porous media equation and the Stokes transport system via energy structure. [PDF]

Calc Var Partial Differ Equ
Park J.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

BdNRT2A and BdNRT3.2 Are the Major Components of the High-Affinity Nitrate Transport System in <i>Brachypodium distachyon</i>. [PDF]

Plant Direct
David LC, Grégoire M, Berquin P, Marmagne A, Dalmais M, Bendahmane A, Miller TJ, Krapp A, Daniel-Vedele F, Girin T, Ferrario-Méry S.   +10 more
europepmc   +1 more source

The effects and conflicts of co-opetition in a rail-water multimodal transport system. [PDF]

Ann Oper Res, 2023
Liu J, Xu H, Chen J.
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Consumption of Dietary <i>Premna microphylla</i> Turcz Leaf Alleviates Functional Constipation via Regulating Gut Microbiota and Aquaporins Transport System in Rats. [PDF]

Foods
Wang N, Zhang M, Zhang L, Ren D, Zhao Y, Yang X.   +5 more
europepmc   +1 more source