Results 181 to 190 of about 4,229,632 (317)

ICED OUT: integrated cold-chain eliminating disease outreach. Piloting a motorcycle-enabled laboratory transport system combatting visceral leishmaniasis in rural Kenya. [PDF]

Front Public Health
Chang A, Kitondo M, Obwavo E, Nyakundi H, Wamai R.   +4 more
europepmc   +1 more source

Continuous, long-term crawling behavior characterized by a robotic transport system. [PDF]

Elife, 2023
Yu J, Dancausse S, Paz M, Faderin T, Gaviria M, Shomar JW, Zucker D, Venkatachalam V, Klein M.   +8 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The TonB-Dependent Transport System Facilitates the Uptake of Inorganic Metal Mediators in Pseudomonas putida KT2440 in a Bioelectrochemical System. [PDF]

Microb Biotechnol
Weimer A, Krömer J, Lai B, Wittmann C.
europepmc   +1 more source

More sustainable tomorrow’s transport systems based onBig Data concerning travel preferences

, 2020
Grzegorz Sierpiński
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Advances in Small Molecule Inhibitors Targeting the Bacterial Lipoprotein Transport System (Lol) in Gram-Negative Bacteria. [PDF]

Chem Asian J
Song S, Shim SY.
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

ROS-induced allosteric modulation of NikR promotes <i>Helicobacter pylori</i> biofilm formation by attenuating FlgR-dependent inhibition of the molybdate transport system. [PDF]

Virulence
Zheng Y, Li S, Xue J, Zhang L, Wang L, Zhao Y, Zhang W, Ma W, Liu J, Sun Y, Sun Y.   +10 more
europepmc   +1 more source

Efficacy of a Swab Transport System in Maintaining Viability of Neisseria gonorrhoeae and Streptococcus pneumoniae

, 2001
Shaker E. Farhat, Mary Thibault, Roslyn Devlin   +2 more
openalex   +1 more source