Results 141 to 150 of about 1,006,093 (289)

Web-Based Roadway Geometry Design Software for Transportation Education [PDF]

open access: yes
Traditionally, students use pencil and ruler to lay out lines and curves over contour maps for roadway geometry design. Numerous calculations of stopping sight distance, minimum turning radius, and curve alignments are required during the roadway design ...
Chen-Fu Liao, David Levinson
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

Flight elements: Advanced avionics systems architectures [PDF]

open access: yes
Space transportation objectives are associated with transporting material from Earth to orbit, interplanetary travel, and planetary landing. The objectives considered herein are associated with Earth to orbit transportation.

core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Carbon emission quantification analysis of excavation engineering under road transport conditions.

open access: yesPLoS ONE
Current research on building carbon emissions primarily focuses on various carbon emission assessment models and the use of life cycle analysis to evaluate overall building carbon emissions, with limited attention given to excavation engineering.
Bai Chongxi, Zhiheng Zhang
doaj   +1 more source

Technology transfer: Transportation [PDF]

open access: yes
Standard Research Institute (SRI) has operated a NASA-sponsored team for four years. The SRI Team is concentrating on solving problems in the public transportation area and on developing methods for decreasing the time gap between the development and the
Anyos, T., Lizak, R., Merrifield, D.
core   +1 more source

Home - About - Disclaimer - Privacy