Results 141 to 150 of about 5,497,503 (307)

Investing in transportation to keep Texas economically competitive [PDF]

This current report, It's About Time: Investing in Transportation to Keep TexasEconomically Competitive, updates the February 2009 report by providingan enhanced analysis of the current state of the Texas transportation system,determining the household ...
Texas. Transportation Commission
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Development of a special topics course on civil engineering project finance for the Zachry Department of Civil Engineering of Texas A&M University. [PDF]

DTRT06-G-0044Experts predict that the highway trust fund will deteriorate rapidly over the course of the next severalyears. This situation has led many state agencies to seek alternative financing methods that can meet bothsocial and economic needs.
Aslan, Zafer, Texas Transportation Institute. University Transportation Center for Mobility, Damnjanovic, Ivan   +2 more
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Transportation engineering for enhanced production of plant natural products in microbial cell factories. [PDF]

Synth Syst Biotechnol
Zuo Y, Zhao M, Gou Y, Huang L, Xu Z, Lian J.   +5 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Midwest Transportation Consortium : 2009-2010 annual report. [PDF]

In October 2009, the Midwest Transportation Consortium (MTC) began its third yearas a Tier I University Transportation Center (UTC). Its theme, \u201cTransportation Safetythrough Improvements in Management Information Systems,\u201d reflects our ...
Midwest Transportation Consortium
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SLRV Engineering Tests at Department of Transportation Transportation Test Center: Volume III--Ride Quality, Noise, and Radio Frequency Interference

DOT-TSC-1062The SLRV (Standard Light Rail Vehicle) is a 71-foot vehicle, articulated to negotiate curves down to a 32-foot radius and designed to operate at speeds up to 50 mph.
Boeing Vertol Company, John A. Volpe National Transportation Systems Center (U.S.)   +1 more
core   +1 more source

Mechanical, Durability, Carbon Footprint, and Economic Assessment of Sand-Gravel-Gneiss Aggregate Mixtures for Sustainable Road Construction. [PDF]

Materials (Basel)
Nowaczek A, Kulczycka J, Bęben M, Kasperek D, Kowalski Z, Makara A, Generowicz-Caba N.   +6 more
europepmc   +1 more source