Results 151 to 160 of about 3,857,178 (370)

Flight elements: Advanced avionics systems architectures [PDF]

open access: yes
Space transportation objectives are associated with transporting material from Earth to orbit, interplanetary travel, and planetary landing. The objectives considered herein are associated with Earth to orbit transportation.

core   +1 more source

An Optimization Model for Single-Warehouse Multi-Agents Distribution Network Problems under Varying of Transportation Facilities: A Case Study [PDF]

open access: yes, 2008
The transportation cost of goods is the highest day-to-day operational cost associated with the food industry sector. A company may be able to reduce logistics cost and simultaneously improve service level by optimizing
Fauziati, Alfin Nuriya   +3 more
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Assessing The Potential for Transportation Mode Switching in Mid-Sized Urban Areas using Binary Logistic Regression

open access: yesAceh International Journal of Science and Technology
Cities without public transport will suffer several issues, such as congestion, limited productive time, and a lower quality of life. The present study investigates various factors influencing public transportation choices in mid-sized urban, including ...
Said Basalim, Akhmadali Akhmadali
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

Progress on coal-derived fuels for aviation systems [PDF]

open access: yes
The results of engineering studies of coal-derived aviation fuels and their potential application to the air transportation system are presented. Synthetic aviation kerosene (SYN.
Witcofski, R. D.
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

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