Results 41 to 50 of about 1,885,759 (302)

Coupled membrane transporters reduce noise [PDF]

Physical Review E, 2020
Molecular systems are inherently probabilistic and operate in a noisy environment, yet, despite all these uncertainties, molecular functions are surprisingly reliable and robust. The principles used by natural systems to deal with noise are still not well understood, especially in a nonhomogeneous environment where molecules can diffuse across ...
Luca Cardelli, Luca Laurenti, Attila Csikasz-Nagy   +2 more
openaire   +3 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Experimental Study on the Rail Damper for Vibration and Noise Control and Rail Corrugation Suppression

Urban Rail Transit
With the rapid construction of rail transportation infrastructure, vibration issues caused by wheel–rail interactions during train operation have become a significant concern.
Fangqiu Sun, Zhiqiang Sun, Ruihua Liang, Deyun Ding, Meng Ma   +4 more
doaj   +1 more source

Spatial assessment of the attributable burden of disease due to transportation noise in England

Environment International, 2023
Background: Noise pollution from transportation is one of the leading contributors to the environmental disease burden in Europe. We provide a novel assessment of spatial variations of these health impacts within a country, using England as an example ...
Calvin Jephcote, Sierra N. Clark, Anna L. Hansell, Nigel Jones, Yingxin Chen, Claire Blackmore, Katie Eminson, Megan Evans, Xiangpu Gong, Kathryn Adams, Georgia Rodgers, Benjamin Fenech, John Gulliver   +12 more
doaj   +1 more source

Fluctuating noise drives Brownian transport [PDF]

Journal of The Royal Society Interface, 2012
The transport properties of Brownian ratchet were studied in the presence of stochastic intensity noise in both overdamped and underdamped regimes. In the overdamped case, an analytical solution using the matrix-continued fraction method revealed the existence of a maximum current when the noise intensity fluctuates on intermediate ...
Hasegawa, Yoshihiko, Arita, Masanori
openaire   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Association between transportation noise and blood pressure in adults living in multi-storey residential buildings

Environment International, 2019
Epidemiological studies have demonstrated that transportation noise is associated with blood pressure and hypertension, but little is known about its relationship in the adults living in multi-storey residential buildings, where neighbour noise is ...
Pyoung Jik Lee, Sang Hee Park, Jeong Ho Jeong, Taeryang Choung, Kwan Yong Kim   +4 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

LDP and CLT for SPDEs with transport noise

Stochastics and Partial Differential Equations: Analysis and Computations, 2023
AbstractIn this work we consider solutions to stochastic partial differential equations with transport noise, which are known to converge, in a suitable scaling limit, to solution of the corresponding deterministic PDE with an additional viscosity term.
Lucio Galeati, Dejun Luo
openaire   +5 more sources