Results 121 to 130 of about 487,951 (354)

Basic Aspects of Interhospital Transportation of Critically Ill Patients with Polytrauma

Общая реаниматология, 2006
Polytrauma is one of the main causes of death in modern medicine. It is characterized by the particular severity of clinical manifestations and attended by significant impairments of the body’s vital functions, by diagnostic difficulties, and treatment ...
V. V. Agadzhanyan, A. V. Shatalin, S. A. Kravtsov, D. A. Skopintsev, S. V. Vlasov, O. A. Karlova   +5 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Transportation is a Barrier to Healthcare in Central Vermont [PDF]

, 2016
Transportation is a significant barrier to healthcare access in Central Vermont due to a variety of reasons that include low income households, poor access to public transportation, elderly populations, and populations with disabilities. Improving access
Trivedi, Apoorva
core   +1 more source

Clinical reconciliation of patient social context and implementation of preventive care guidelines [PDF]

, 2020
Background Preventive care practice guidelines are disseminated regularly through federal and scientific groups as a way of promoting best practices and evidence-based health promotion.
Williams, April
core   +1 more source

Transportation Cost Is a Significant Barrier to Quality Care for Hematologic Malignancy Patients in a Minority-Rich, Socioeconomically Disadvantaged Population [PDF]

, 2023
Lauren Laufer, Lemchukwu Amaeshi, Alex Sisto, Kateryna Fedorov, Rosmi Mathew, David Levitz, Ioannis Mantzaris, Noah Kornblum, Mendel Goldfinger, Alejandro Sica, Dennis Cooper, Marina Konopleva, Bruce D. Rapkin, Amit Verma, Aditi Shastri, Nishi Shah   +15 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Interhospitalni i intrahospitalni transport kritično povređenih i obolelih [PDF]

Vojnosanitetski Pregled, 2004
Filipović Nikola, Šurbatović Maja, Stanković Nebojša, Jovanović Krsta   +3 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Breaking the Barriers to Specialty Care: Practical Ideas to Improve Health Equity and Reduce Cost - Increasing Specialty Care Availability [PDF]

, 2016
Tremendous health outcome inequities remain in the U.S. across race and ethnicity, gender and sexual orientation, socio-economic status, and geography—particularly for those with serious conditions such as lung or skin cancer, HIV/AIDS, or cardiovascular
Chris Carlson, Jared Sholk, Jennifer Nanni, Kyle Peterson, Lauren A. Smith, Neeraja Bhavaraju   +5 more
core  

The Working Process and Time Efficiency of Patient Transportation in Cardiovascular Hospital Using Time Process Modeling [PDF]

, 2010
Hiroko Ojima, Yuko Ohno, Sachiko Shimizu, Shintaroh Oi, Yasuko Inoue, Ishii Atsue, Satoko Kasahara, Katsumi Hirakawa, Shohei Nakamura, Ichiro Kanaya, Kazuo Kawasaki, Atsuko Tanaka, Fujie Motosugi, Chizuru Okada   +13 more
openalex   +1 more source