Results 151 to 160 of about 487,951 (354)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
New York City's Chinatown has been heavily impacted by air pollution. The Chinese Progressive Association (CPA) designed this survey to get a more complete picture of the asthma problem in the Chinatown area.
core
Study for Emergency Patients Transportation System in Korea [PDF]
Byung Kwon Choi +3 more
openalex +1 more source
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Safety Net hospital Emergency Departments: Creating Safety Valves for Non-urgent Care [PDF]
Outlines how safety-net hospitals are addressing the rise in emergency department visits for non-urgent care, such as re-directing patients to outpatient clinics or community health centers and adding primary care capacity.
Laurie E. Felland +2 more
core
Outcome of the critically ill patient brought to emergency department and their mode of transportation [PDF]
Umakanta Tiwari +6 more
openalex +1 more source
Background Minimising time from injury to hospital admission is considered a key factor in trauma. Trauma care is often centralised to hospitals, which, because of their urban location, make treatment more accessible to patients in densely populated ...
Oscar H. M. Lundberg +2 more
doaj +1 more source

