Results 131 to 140 of about 365,847 (307)

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

09-05 "The Environmental Impacts of Soybean Expansion and Infrastructure Development in Brazil’s Amazon Basin" [PDF]

open access: yes
For decades, the development of transportation infrastructure in the Brazilian Amazon has been the government’s main social and economic development policy in the region.
Daniel C. Nepstad   +2 more
core  

Study on behavioral impedance for route planning techniques from the pedestrian's perspective: Part I - Theoretical contextualization and taxonomy [PDF]

open access: yes, 2001
The interest of researchers for analyzing of best routes and shortest paths allows a continuous technological advance in topological analysis techniques used in the geographic information systems for transportation.
Nogueira, Durval Lordelo   +2 more
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

open access: yesFEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa   +2 more
wiley   +1 more source

LAS REDES DE INFRAESTRUCTURAS VIARIAS DE TRANSPORTES TERRESTRES ENTRE LA PENÍNSULA IBÉRICA Y FRANCIA; DESCOORDINACIÓN E INSUFICIENCIAS

open access: yesPapeles de Geografí­a, 2004
Los transportes terrestres, carreteras y ferrocarril, alcanzan una significación destacada en sus diferentes aspectos en la Unión Europea. Por otro lado, las redes de infraestructuras tienen un marcado carácter nacional.
José Mª Serrano Martínez
doaj  

End of the line: Railroads in Chile [PDF]

open access: yes
Between 1860 and 1950, railroads in Chile were synonym of modernization, integration, and economic development. By the 1970s railroads were bankrupt and socially discredited, surviving out of government subsidies.
Raimundo Soto
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Income inequality in central Spain, 1690-1800 [PDF]

open access: yes
This paper studies the evolution of income inequality in central Spain during the late seventeenth and eighteenth centuries, taking as case study the province of Guadalajara.
Carlos Santiago Caballero
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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