Results 31 to 40 of about 10,061 (275)

L’organisation interterritoriale des transports publics dans les Alpes-Maritimes (2008-2018) : conflits d’acteurs, empilement et discordances des structures politiques

open access: yesL'Espace Politique, 2020
Organization of AOMU, through the making of a unique transport structure in the urban area of French Riviera have a major role in the inter-territoriality management between transports policies.
Julian Courteix
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

open access: yesFEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez   +2 more
wiley   +1 more source

La digitalisation des documents administratifs au ministère des transports : impacts et enjeux

open access: yesAkofena
Résumé : La digitalisation des services publics est un levier essentiel pour améliorer les indicateurs de développement des entreprises. Elle permet d’accroître l’efficacité, la transparence et la qualité des services administratifs.
Kouamé KOFFI
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Crise des transports publics : des issues possibles ?

open access: yes, 2001
National audienceLes difficultés du financement des transports publics urbains ne sont pas nouvelles. Elles ont même une histoire qui, à quelques années près, a été scandée de manière quasiment identique dans le monde industrialisé.
Bonnafous, Alain
core   +1 more source

Open data, usagers du numérique et entreprises publiques

open access: yesRevue Française des Sciences de l’Information et de la Communication, 2015
The circulation of informations and relations between web 2.0 users and companies show a bottom-up and top-down flows: a growing participation of citizens—through opinions or suggestions—, and a progressive opening of company database.
Bruno Asdourian, Virginie Zimmerli
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

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