Results 51 to 60 of about 10,061 (275)

Du citoyen et de la « civilité ». Réflexions à partir de l’exemple de la vidéosurveillance

Lien Social et Politiques, 2007
Dans la foulée des événements du 11 septembre 2001, la problématique des incivilités permet de légitimer des politiques sécuritaires souvent musclées. Comment cette situation influence-t-elle les relations entre l’État et le citoyen ?
Jean Ruegg, Francisco Klauser, Valérie November   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Des transports publics pour tous ? Une évaluation des arrêts de la STIB à Bruxelles

Brussels Studies
This paper analyses the state of public transport (PT) stops in Brussels through the lens of inclusiveness for disabled persons. The approach mixes qualitative perspectives (including talks and field trips with numerous NGOs, disabled individuals using ...
Frédéric Dobruszkes, Martin Grandjean, Arthur Nihoul, Julien Descamps   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

LA MEDIATISATION DU KIDNAPPING A KINSHASA : ENTRE PSYCHOSE COLLECTIVE, « SYNOPTICON » DES RESEAUX SOCIAUX ET REACTION SOCIALE [PDF]

Ziglôbitha
Résumé : Cet article propose une analyse clinique de la mutation profonde des dynamiques criminelles au sein de la métropole de Kinshasa, marquée par le basculement d'une violence artisanale et territorialisée, typique du phénomène Kuluna, vers une ...
Moïse BANGANI NGUAMU, Raoul KIENGE-KIENGE INTUDI & Joël NZAMPUNGU IMBOLE
doaj   +1 more source

La tarification des transports publics

, 2005
ISSN : 0008-0217Cet article décrit les différentes modalités de tarifications à l'aide d'exemples chiffrés simples. La tarification des transports publics constitue la clé de voûte de l'équilibre en visant également l'orientation de la demande globale de
Croissant, Yves, Bonnafous, Alain
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

L'insécurité dans les transports publics urbains : bibliographie commentée

, 2003
Depuis 15 ans, les situations de violence s’aggravent dans les transports publics quels qu’ils soient et le sentiment d’insécurité progresse tant chez le personnel que parmi les usagers.
Crossonneau, Nicolas
core   +2 more sources