Results 51 to 60 of about 339 (204)
Geography NotebooksPublic Transport and Urban Planning in Greater Rabat: In Search of a Balanced Management between Urbanization and Mobility Public transport worldwide faces major challenges such as congestion, delays, high costs, and safety concerns, further complicated
Ikrame Laadssi, Mohamed Hanzaz
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Le boom du raffinage en Asie du Sud-Est Refinery Boom in Southeast Asia
Oil & Gas Science and Technology, 2006 Le marché pétrolier connaît en Asie un développement rapide, principalement dans la zone non OCDE, qui représente aujourd'hui plus de 15 % de la consommation pétrolière mondiale. La croissance économique attendue dans ces pays devrait porter cette part à
Gruson J. F., Virondaud C.
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
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On losing the "dispensable" sense: TikTok imitation publics and COVID-19 smell loss challenges. [PDF]
Media Cult Soc, 2023 Michell AG.
europepmc +1 more source
Brussels StudiesThis paper investigates the gap in PT access to the city faced by disabled people when using public transport in Brussels. The research is carried out at the route level from all STIB-MIVB stops to 20 selected destinations across the city.
Frédéric Dobruszkes +2 more
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Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Toward Sustainable Mobility: AI-Enabled Automated Refueling for Fuel Cell Electric Vehicles
EnergiesWith the global transportation sector being a major contributor to greenhouse gas (GHG) emissions, transitioning to cleaner and more efficient forms of transportation is essential for mitigating climate change and improving air quality.
Sofia Polymeni +6 more
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Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source