Results 101 to 110 of about 2,371,477 (389)

Genomic Selective Constraints in Murid Noncoding DNA [PDF]

, 2006
Recent work has suggested that there are many more selectively constrained, functional noncoding than coding sites in mammalian genomes. However, little is known about how selective constraint varies amongst different classes of noncoding DNA.
Altschul, Bejerano, Bejerano, Boissinot, Bray, Britten, Casane, Chamary, Chamary, Cooper, Cooper, Daniel J. Gaffney, Deininger, Dermitzakis, Dermitzakis, Dermitzakis, Eisenberg, Eyre-Walker, Fairbrother, Frazer, Gaffney, Gibbs, Hanawalt, Hubbard, Jaeger, Kamal, Keightley, Keightley, Keightley, Keightley, Kimura, Kondrashov, Kondrashov, Lander, Li, Margulies, Meunier, Mi, Mikkelsen, Nagylaki, Nelson, Parmley, Peter D. Keightley, Seoighe, Siepel, Sironi, Sorek, Tamura, Thomas, Thompson, Urrutia, Vinogradov, Vinogradov, Waterston, Webster, Yelin   +55 more
core   +3 more sources

Evolvability, epigenetics and transposable elements

BioMolecular Concepts, 2011
AbstractEvolvability can be defined as the capacity of an individual to evolve and thus to capture adaptive mutations. Transposable elements (TE) are an important source of mutations in organisms. Their capacity to transpose within a genome, sometimes at a high rate, and their copy number regulation are environment-sensitive, as are the epigenetic ...
Fablet, Marie, Vieira, C.
openaire   +7 more sources

Molecular dissection of a natural transposable element invasion

Genome Research, 2018
The first tracking of the dynamics of a natural invasion by a transposable element (TE) provides unprecedented details on the establishment of host defense mechanisms against TEs. We captured a D.
R. Kofler, K. Senti, V. Nolte, R. Tobler, C. Schlötterer   +4 more
semanticscholar   +1 more source

Open‐source deep‐learning models for segmentation of normal structures for prostatic and gynecological high‐dose‐rate brachytherapy: Comparison of architectures

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background The use of deep learning‐based auto‐contouring algorithms in various treatment planning services is increasingly common. There is a notable deficit of commercially or publicly available models trained on large or diverse datasets containing high‐dose‐rate (HDR) brachytherapy treatment scans, leading to poor performance on images ...
Andrew J. Krupien, Yasin Abdulkadir, Dishane C. Luximon, John Charters, Huiming Dong, Jonathan Pham, Dylan O'Connell, Jack Neylon, James M. Lamb   +8 more
wiley   +1 more source

Progressive Myoclonus Epilepsy: Distinctive MRI Changes in Cerebellar and Motor Networks

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progressive myoclonus epilepsy (PME) is a rare generalized epilepsy syndrome with a well‐characterized genetic basis. The brain networks that are affected to give rise to the distinctive symptoms of PME are less well understood. Methods Eleven individuals with PME with a confirmed genetic diagnosis and 22 controls were studied.
Jillian M. Cameron, Remika Mito, Samuel F. Berkovic, Graeme D. Jackson   +3 more
wiley   +1 more source

Contrasting patterns of transposable element insertions in Drosophila heat-shock promoters. [PDF]

PLoS ONE, 2009
The proximal promoter regions of heat-shock genes harbor a remarkable number of P transposable element (TE) insertions relative to both positive and negative control proximal promoter regions in natural populations of Drosophila melanogaster.
Robert A Haney, Martin E Feder
doaj   +1 more source

On orders of elements of finite almost simple groups with linear or unitary socle [PDF]

J. Group Theory 20 (2017), 1191-1222, 2016
We say that a finite almost simple $G$ with socle $S$ is admissible (with respect to the spectrum) if $G$ and $S$ have the same sets of orders of elements. Let $L$ be a finite simple linear or unitary group of dimension at least three over a field of odd characteristic. We describe admissible almost simple groups with socle $L$.
arxiv   +1 more source

Dynamics of Transposable Element Invasions with piRNA Clusters

bioRxiv, 2018
In mammals and in invertebrates the proliferation of a newly invading transposable element (TE) is thought to be stopped by a random insertion of one member of the invading TE family into a piRNA cluster. This view is known as the trap model.
R. Kofler
semanticscholar   +1 more source

Cerebello‐Prefrontal Connectivity Underlying Cognitive Dysfunction in Spinocerebellar Ataxia Type 2

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 2 (SCA2) is a hereditary cerebellar degenerative disorder, with motor and cognitive symptoms. The constellation of cognitive symptoms due to cerebellar degeneration is named cerebellar cognitive affective syndrome (CCAS), which has increasingly been recognized to profoundly impact patients' quality of life;
Ami Kumar, Ruo‐Yah Lai, Zena Fadel, Yicheng Lin, Pia Parekh, Rachel Griep, Ming‐Kai Pan, Sheng‐Han Kuo   +7 more
wiley   +1 more source

Cerebral Amyloid Angiopathy Is Associated With Higher R2 Relaxation Rate: An MRI and Pathology Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebral amyloid angiopathy (CAA) involves β‐amyloid deposition in the walls of cortical and leptomeningeal small vessels. Transverse relaxation rate (R2) is a major source of contrast in MRI. This study tested the hypothesis that CAA is associated with R2, extracted the spatial pattern of CAA‐related R2 abnormalities, and evaluated ...
Md Tahmid Yasar, Arnold M. Evia, Mahir Tazwar, Sue E. Leurgans, David A. Bennett, Julie A. Schneider, Konstantinos Arfanakis   +6 more
wiley   +1 more source