Results 271 to 280 of about 68,477 (364)

Gene-sized DNA insertion at genomic safe harbors in human cells using a site-directed transposase. [PDF]

Nucleic Acids Res
Short JE, Sharek L, Meckler JF, Stoytchev I, Tran CT, Errard C, Hew BE, Johnson BE, Waller DF, Xie S, Higgins JJ, Tabibiazar R, Owens JB.   +12 more
europepmc   +1 more source

Domesticated transposase Kat1 and its fossil imprints induce sexual differentiation in yeast

Proceedings of the National Academy of Sciences of the United States of America, 2014
Naghmeh Rajaei, K. K. Chiruvella, F. Lin, S. Åström   +3 more
semanticscholar   +1 more source

Regulation of Immune Checkpoints: From Molecular Mechanisms to Clinical Therapies

MedComm, Volume 7, Issue 6, June 2026.
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by unleashing antitumor immunity. This review comprehensively examines the molecular mechanisms underlying key immune checkpoints—including PD‐1/PD‐L1, CTLA‐4, and TIM‐3—and their clinical applications.
Qintao Ge, Liu Yu, Jiahe Lu, Aihetaimujiang Anwaier, Xiyue Xiao, Yonghao Chen, Dingwei Ye, Hailiang Zhang, Wenhao Xu, Wenbin Dai   +9 more
wiley   +1 more source

Sequence bias in chromatin fragmentation leads to misinterpretation of protein-DNA interactions in vivo. [PDF]

Genome Biol
Durán L, Rodríguez L, García A, Santamaría R, Sánchez M, Antequera F.   +5 more
europepmc   +1 more source

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang, Qitai Chen, YuJie Yu, Yi Zang, Rujia Zheng, Zhe Zhang, Shuaijun Lu, Li Zhou   +7 more
wiley   +1 more source

The novel pseudo-compound transposon Tn<i>7086</i> carries aminoglycoside resistance genes in <i>Enterococcus faecalis</i>. [PDF]

Microb Genom
Colombini L, Tirziu M, De Giorgi S, Cuppone AM, Sangiorgio G, Bonomo C, Bongiorno D, Stefani S, Ricci S, Pozzi G, Santoro F, Iannelli F.   +11 more
europepmc   +1 more source

NMR structural analysis of Sleeping Beauty transposase binding to DNA

Protein Science, 2014
Claire Carpentier, Jeffrey M. Schreifels, E. Aronovich, D. F. Carlson, P. Hackett, I. Nesmelova   +5 more
semanticscholar   +1 more source

CHD4 Orchestrates Chromatin Remodeling to Activate the c‐Myc Signaling Pathway in Cancer Pathogenesis

MedComm – Oncology, Volume 5, Issue 2, June 2026.
CHD4 plays an essential role as an epigenetic regulator in the pathogenesis of multiple myeloma. The chromatin remodeling protein initially resolves G‐quadruplex (G4) secondary structures within the c‐Myc promoter region, thereby enhancing chromatin accessibility and promoting transcriptional activation.
Pinggang Ding, Yuhao Cao, Zihao Liu, Jingru Xie, Lingling Liu, Shanliang Sun, Xichao Yu, Zhendong Deng, Zhimin Fan, Ye Yang, Chunyan Gu   +10 more
wiley   +1 more source

Sequential, chromosome-specific glutamine synthetase double knockout with Cas-CLOVER establishes enhanced CHO platforms for cell line development. [PDF]

Biotechnol Prog
Limia CG, Steffey V, Cheng HC, Machado D, Hart T, McHargue MC, Brizzee C, Crawford J.   +7 more
europepmc   +1 more source

Transposase-Derived Transcription Factors Regulate Light Signaling in Arabidopsis

Science, 2007
Rongcheng Lin, L. Ding, C. Casola, D. Ripoll, C. Feschotte, Haiyang Wang   +5 more
semanticscholar   +1 more source