Results 51 to 60 of about 265,737 (174)
Tumor‐Derived Exosomal piR‐hsa‐28212 Promotes Lymphatic Metastasis in Breast Cancer
Cancer Science, EarlyView.Breast cancer–derived exosomal piR‐hsa‐28212 promotes lymphangiogenesis and lymph node metastasis by activating VEGFC/VEGFR3 signaling. It stabilizes TBX1 mRNA in lymphatic endothelial cells and METTL3 protein in tumor cells, enhancing VEGFR3 expression and VEGFC secretion.
Yafen Wang +7 more
wiley +1 more source
, 1973 A non-transposing mute having a metallic hemispherical resonator with a hollow acoustic filter attached thereto is provided for detachably fitting upon the rim of a brass musical instrument.
Schneider, Karl A., Gossick, Benjamin R.
core +1 more source
MEN1 Deficiency Drives Lung Cancer Progression via Activation of MMP10‐Mediated Angiogenesis
Cancer Science, EarlyView.MEN1 deficiency promotes JunD‐mediated upregulation of MMP10 expression, which cleaves pro‐HB‐EGF and activates endothelial EGFR. This triggers the PI3K/Akt and MEK/ERK signaling pathways, thereby driving angiogenesis and tumor progression. MMP10 inhibitor treatment blocks this cleavage, suppresses EGFR signaling, and thereby delays malignant ...
Chengyu Wei +17 more
wiley +1 more source
, 2021 Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disease caused by a mutation in LMNA. A G608G mutation in exon 11 of LMNA is responsible for most HGPS cases, generating a truncated protein called “progerin”.
Karima Djabali +2 more
core +1 more source
Clinical Genetics, EarlyView.A homozygous truncating variant in LRGUK results in loss of the LRGUK protein and causes multiple morphological abnormalities of the flagella (MMAF), disrupted axonemal architecture, central pair defects, abnormal chromatin organization, and severe male infertility, establishing LRGUK as a novel human infertility gene.
Wiâme Mokkedem +14 more
wiley +1 more source
Efficient amplitude-modulated pulses for triple- to single-quantum coherence conversion in MQMAS NMR [PDF]
, 2014 We thank EPSRC (EP/E041825/1 and EP/J501542/1) for support, for the award of a studentship to H.C. We also thank the ERC (EU FP7 Consolidator Grant 614290 “EXONMR”).The conversion between multiple- and single-quantum coherences is integral to many ...
Dawson, Daniel M +5 more
core +1 more source
Transposing 4-Letter Words [PDF]
, 2007 In Transposing Rates (WW87195), Jeff Grant listed the 24 transpositions of the four letters AEST. He said Although some of the terms and references are rather obscure, it is an accomplishment unlikely to be equalled with any other set of four letters ...
Thorpe, Susan
core +1 more source
The FEBS Journal, EarlyView.We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti +11 more
wiley +1 more source
Transgenic selection and underlying mechanisms in apicomplexan parasites
The FEBS Journal, EarlyView.Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju +2 more
wiley +1 more source
Neutron- and neutrino-induced reactions : their physical description and influence on r-process calculations [PDF]
, 2006 When I started this thesis my supervisors F. K. Thielemann and T. Rauscher spoke to me enthusiastically about the exciting and interesting field of nuclear astrophysics at our very first meeting.
Mocelj, Darko
core +1 more source