Results 181 to 190 of about 12,801 (247)
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song +6 more
wiley +1 more source
Placental Dysfunction and Congenital Heart Disease: Investigating the Placenta‐Heart Axis
ABSTRACT Objective Concurrent development of the placenta and heart during early gestation suggests a shared biological basis for the co‐occurrence of abnormal placentation and congenital heart disease (CHD). This study investigated the association between placental vascular pathology and CHD type.
Natalie Lanners +10 more
wiley +1 more source
ABSTRACT Pulmonary hypertension (PH) and right ventricular (RV) dysfunction increase mortality in multivessel pediatric pulmonary vein stenosis (PVS). Pulmonary vasodilator use is limited in PVS due to the perceived risk of pulmonary edema. We aimed to describe our experience with pulmonary vasodilators in PVS and to assess changes in RV function and ...
Catherine M. Avitabile +8 more
wiley +1 more source
Iron Homeostasis at High Altitude in Patients With Pulmonary Hypertension
ABSTRACT Iron deficiency aggravates hypoxic pulmonary vasoconstriction, exacerbating the increase of pulmonary arterial pressure at high altitude (HA). This may be especially relevant for patients with pulmonary hypertension (PH) travelling to HA, who moreover have a high prevalence of iron deficiency. Currently, no data is available on iron parameters
Aurelia E. Reiser +11 more
wiley +1 more source
Evidence for PDZ‐Binding Kinase in Lung Disease With an Emphasis on PAH
ABSTRACT Originally named T‐cell‐originated Lymphokine‐activated killer protein kinase (TOPK), PDZ‐Binding Kinase (PBK) is a serine/threonine kinase that is a member of the family of mitogen‐activated protein kinases (MAPKKs), which is overexpressed in lung cancer and interstitial pulmonary fibrosis (IPF). Along these lines, recent work also shows that
Scott A. Barman +2 more
wiley +1 more source
Prenatal detection and outcome of major heart defects in a country with universal screening
ABSTRACT Objective To evaluate the Danish prenatal screening program for major fetal congenital heart defects (mCHD), focusing on incidence, detection rates (DRs), pregnancy outcomes and postnatal mortality. Methods This was a 5‐year nationwide cohort study conducted from January 2018 to December 2022 in Denmark.
C. Vedel +15 more
wiley +1 more source
How to facilitate ultrasound examination of the fetal heart: the 5‐4‐3‐2‐1 method
ABSTRACT We propose a new standardized, systematic method of fetal cardiac screening, the step‐by‐step ‘5‐4‐3‐2‐1’ method. This method is based on understanding the cardiac structures through a process of navigating between the different recommended views during an abdominothoracic sweep, following a user‐friendly checklist to identify the main ...
M. Levy, B. Stos
wiley +1 more source
Development of Ultrasound Microbubbles and Phase Shift Microbubbles in Theranostics
Microbubbles have been originally designed for diagnostic applications. Over the years, microbubbles and phase shift microbubbles have been further developed for therapeutic indications. ABSTRACT Ultrasound is widely used for diagnostic imaging and therapy.
Emmanuelle J. Meuillet, Evan C. Unger
wiley +1 more source
The evolution of hierarchical phase‐contrast tomography (HiP‐CT) from its origins at the BM05 beamline to its transition to BM18 (ESRF‐EBS) is shown. The novel hardware and scanning approach developments resulted in significantly improved data quality, resolution, sensitivity and speed.
Hector Dejea +9 more
wiley +1 more source

