Results 301 to 310 of about 60,909 (346)
Some of the next articles are maybe not open access.
RNA-targeting and gene editing therapies for transthyretin amyloidosis
Nature Reviews Cardiology, 2022Alberto Aimo +2 more
exaly +2 more sources
Hereditary transthyretin amyloidosis: a model of medical progress for a fatal disease
Nature Reviews Neurology, 2019David Adams, Haruki Koike
exaly +2 more sources
Transthyretin amyloid cardiomyopathy
Medicina Clínica (English Edition), 2021Transthyretin (TTR) cardiac amyloidosis is a severe, progressive, infiltrative disease caused by the deposition of TTR at cardiac level. It may be due to a genetic alteration in its hereditary form (ATTRv) or as a consequence of an age-related degenerative process (ATTRwt). Thanks to advances in imaging techniques and the possibility of achieving a non-
Pablo García-Pavía +2 more
openaire +3 more sources
A molecular mechanism for transthyretin amyloidogenesis [PDF]
Nature Communications, 2019 AbstractHuman transthyretin (TTR) is implicated in several fatal forms of amyloidosis. Many mutations of TTR have been identified; most of these are pathogenic, but some offer protective effects. The molecular basis underlying the vastly different fibrillation behaviours of these TTR mutants is poorly understood.
Alycia, Ai Woon Yee +2 more
exaly +12 more sources
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 1995
A cDNA library was constructed from liver RNA of the Australian diprotodont marsupial Macropus eugenii, the Tammar wallaby. A cloned full-length transthyretin cDNA was sequenced. The derived amino-acid sequence showed 68% overall similarity to that of human transthyretin, with 86% similarity in the thyroxine binding site.
C M, Brack +3 more
openaire +2 more sources
A cDNA library was constructed from liver RNA of the Australian diprotodont marsupial Macropus eugenii, the Tammar wallaby. A cloned full-length transthyretin cDNA was sequenced. The derived amino-acid sequence showed 68% overall similarity to that of human transthyretin, with 86% similarity in the thyroxine binding site.
C M, Brack +3 more
openaire +2 more sources
Computational Studies on Transthyretin
Current Medicinal Chemistry, 2012Among the 23 different fibril proteins described in human amyloidosis, transthyretin is associated with the most common hereditary form of the disease and its knowledge is corroborated through about 150 crystal structures in addition to thousands of small ligands tested as fibril formation inhibitors. In spite of the large amount of available data, the
ORTORE, GABRIELLA MARIA PIA +1 more
openaire +4 more sources