Results 121 to 130 of about 21,545 (230)

Tafamidis Reduces Death and Hospitalization for Acute Heart Failure in Octogenarian Patients With Transthyretin Cardiac Amyloidosis: A Propensity Score–Weighted Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Transthyretin cardiac amyloidosis results from the deposition of misfolded amyloid fibrils in cardiac tissue, leading to progressive heart failure.
Louise Zmuda, Amira Zaroui, Mounira Kharoubi, Emmanuelle Boutin, Frédéric Roca, Silvia Oghina, Emmanuel Teiger, Marie Laurent, Florence Canoui‐Poitrine, Thibaud Damy, Amaury Broussier   +10 more
doaj   +1 more source

Clinical and laboratory test in patients with familial amyloid polyneuropathy (TTR-FAP): differences between symptomatic patients and asymptomatic carriers [PDF]

Introducción: La polineuropatía amiloidótica familiar asociada a transtirretina (PAF-TTR) es una enfermedad causada por el depósito el depósito de amiloide en los tejidos, cuya proteína precursora es la transtirretina.
Buades-Reines, Juan, Gállego-Lezaun, Cristina, Raya-Cruz, Manuel, Ripoll-Vera, Tomás, Usón-Martín, Mercedes   +4 more
core   +1 more source

Renal amyloidosis revisited: amyloid distribution, dynamics and biochemical type [PDF]

, 2017
Background. Renal amyloidosis results from protein misfolding and leads to progressive renal insufficiency. Few data are available concerning the relevance of the histomorphological patterns and the dynamics of the disease process. Methods.
Hopfer, Helmut, Mihatsch, Michael J., Wiech, Thorsten   +2 more
core  

Cardiac Amyloidosis: A Narrative Review of Diagnostic Advances and Emerging Therapies

Biomedicines
Background/Objectives: Cardiac amyloidosis (CA) is an underdiagnosed and potentially life-threatening infiltrative cardiomyopathy characterized by the extracellular deposition of misfolded amyloid fibrils in cardiac tissue. It is most commonly associated
Dana Emilia Movila, Alexandru Catalin Motofelea, Dragos Cozma, Oana Albai, Alexandra Christa Sima, Minodora Andor, Tudor Ciocarlie, Simona Ruxanda Dragan   +7 more
doaj   +1 more source

Evaluation of Therapeutic Oligonucleotides for Familial Amyloid Polyneuropathy in Patient-Derived Hepatocyte-Like Cells

, 2017
Familial amyloid polyneuropathy (FAP) is caused by mutations of the transthyretin (TTR) gene, predominantly expressed in the liver. Two compounds that knockdown TTR, comprising a small interfering RNA (siRNA; ALN-TTR-02) and an antisense oligonucleotide (
Ackermann, E.J. (Elisabeth), Avsar, Y. (Yesim), Chandhok, G. (Gursimran), Fleischhauer, L. (Lutz), Gollob, J. (Jared), Guo, S. (Shuling), Guttmann, S. (Sarah), Monia, B.P. (Brett), Niemietz, C. (Christoph), Sauer, V.D. (Vanessa), Schmidt, H. (Hartmut), Stella, J. (Jaqueline), Zibert, A. (Andree)   +12 more
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Difficulties in the diagnostics of transthyretin amyloidosis with polyneuropathy: a clinical case description

Клиническая практика
BACKGROUND: In clinical practice, diagnosing of systemic transthyretin amyloidosis (ATTR-amyloidosis) with the impairment of the nervous and cardiovascular systems became possible due to the accessibility of genetic diagnostics and due to the growth of ...
Ekaterina S. Ostapchuk, Oleg P. Glinin, Julija V. Alekseeva   +2 more
doaj   +1 more source

Chest pain in a patient with transthyretin cardiac amyloidosis: A case report

Clinical Case Reports
Key Clinical Message Patients with transthyretin cardiac amyloidosis (ATTR‐CM) commonly present with dyspnea, fatigue, and edema. In our case, the main presentation was exertional angina, which was atypical in patients with ATTR‐CM and should be paid ...
Linfeng Xie, Suxin Luo, Bi Huang
doaj   +1 more source

Neuropathologic analysis of Tyr69His TTR variant meningovascular amyloidosis with dementia [PDF]

, 2015

core   +1 more source

A Rare Culprit or an Elusive Culprit in Disguise? Unraveling Wild-Type ATTR Cardiac Amyloidosis in Heart Failure With Reduced Ejection Fraction

Journal of Investigative Medicine High Impact Case Reports
Cardiac amyloidosis (CA) is a rare disorder caused by the deposition of abnormal proteins called amyloid in the myocardium, leading to dysfunction. The 2 most common forms of amyloidosis are AL (light chain) and ATTR (transthyretin).
Jose Loayza Pintado MD, Taiwo Ajani MD, Daniela Hernandez MD, Everardo Cobos MD   +3 more
doaj   +1 more source

Inotersen: new promise for the treatment of hereditary transthyretin amyloidosis

Drug Design, Development and Therapy, 2019
Veena Mathew,1 Annabel K Wang1,2 1Department of Neurology, UCI ALS and Neuromuscular Center, University of California, Irvine, Orange, CA, USA; 2Neurology Section, Tibor Rubin VA Medical Center, Long Beach, CA, USA Abstract: Hereditary transthyretin ...
Mathew V, Wang AK
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