Results 11 to 20 of about 21,545 (230)

Transthyretin amyloidosis [PDF]

Nursing, 2020
Abstract: Cardiac amyloidosis is a poorly understood cause of heart failure and is often undiagnosed. Recent advances in diagnostic testing and understanding of the disease have enhanced the ability of clinicians to detect this disease and provide patients with appropriate treatment.
Renáta Aiglová, Miloš Táborský, Pavla Flodrová, Alexander Schee   +3 more
openaire   +3 more sources

Transthyretin cardiac amyloidosis

Cardiovascular Research, 2022
AbstractTransthyretin cardiac amyloidosis (ATTR-CA) is an increasingly recognized cause of heart failure (HF) and mortality worldwide. Advances in non-invasive diagnosis, coupled with the development of effective treatments, have shifted ATTR-CA from a rare and untreatable disease to a relatively prevalent condition that clinicians should consider on a
Aldostefano Porcari, Marianna Fontana, Julian D Gillmore   +2 more
openaire   +5 more sources

Genetic and Clinical Spectrum of Hereditary Transthyretin Amyloidosis in Brazil. [PDF]

J Peripher Nerv Syst
ABSTRACT Background Transthyretin hereditary amyloidosis (ATTRv) clinical variability has been widely reported, not only across countries and variants but also among families and distinct regions within a single nation. One of the principal challenges in disease management is the accurate determination of age of onset (AOO), which is heterogeneous and ...
Maximiano-Alves G, Lavigne-Moreira C, Simões MV, Galvão AJP, Valicelli FH, Coneglian FS, Vegezzi E, Garibaldi PMM, Tomaselli PJ, Cortese A, Marques W.   +10 more
europepmc   +2 more sources

Transthyretin cardiac amyloidosis.

Medicine and pharmacy reports, 2021
Transthyretin amyloid cardiomyopathy (ATTR-CM) may be an under recognized cause of heart failure (HF). TTR amyloidosis can be inherited, caused by variants in the TTR gene (ATTRv) or by deposition of wild-type TTR protein (ATTRwt), leading to high mortality if untreated.
Tomoaia, Raluca, Beyer, Ruxandra, Manole, Simona, Chirilă, Alina, Dădârlat-Pop, Alexandra, Minciună, Ioan Alexandru, Pop, Dana   +6 more
openaire   +4 more sources

Hereditary transthyretin amyloidosis overview [PDF]

Neurological Sciences, 2020
AbstractHereditary amyloidogenic transthyretin (ATTRv) amyloidosis is a rare autosomal dominantly inherited disorder caused by mutations in the transthyretin (TTR) gene. The pathogenetic model of ATTRv amyloidosis indicates that amyloidogenic, usually missense, mutations destabilize the native TTR favouring the dissociation of the tetramer into ...
Manganelli, Fiore, Fabrizi, Gian Maria, Luigetti, Marco, Mandich, Paola, Mazzeo, Anna, Pareyson, Davide   +5 more
openaire   +5 more sources

Management of transthyretin amyloidosis

Swiss medical weekly, 2021
Transthyretin amyloidosis (ATTR amyloidosis) is a disease caused by deposition of transthyretin fibrils in organs and tissues, which causes their dysfunction. The clinical heterogeneity of ATTR amyloidosis and the variable presentation of symptoms at early disease stages, historically meant treatment delays. Diagnostic tools and therapy options of ATTR
Condoluci, Adalgisa, Théaudin, Marie, Schwotzer, Rahel, Pazhenkottil, Aju P, Arosio, Paolo, Averaimo, Manuela, Bacher, Ulrike, Bode, Peter, Cavalli, Andrea, Dirnhofer, Stefan, Djerbi, Nadia, Dobner, Stephan, Fehr, Thomas, Garofalo, Maura, Gaspert, Ariana, Gerull, Sabine, Heimgartner, Raphael, Hübers, Annemarie, Jung, Hans H, Kessler, Chiara, Knöpfel, Raphael, Laptseva, Natallia, Magini, Giulia, Manka, Robert, Mazzucchelli, Luca, Meyer, Martin, Mihaylova, Violeta, Monney, Pierre, Mylonas, Alessio, Nkoulou, René, Pabst, Thomas, Pfister, Otmar, Rüfer, Axel, Schmidt, Adrian, Seeger, Harald, Stämpfli, Simon F, Stirnimann, Guido, Suter, Thomas, Treglia, Giorgio, Tzankov, Alexandar, Vetter, Friederike, Zweier, Markus, Flammer, Andreas J, Gerber, Bernhard   +43 more
openaire   +5 more sources

Multidisciplinary Approaches for Transthyretin Amyloidosis [PDF]

Cardiology and Therapy, 2021
Amyloidosis caused by systemic deposition of transthyretin (TTR) is called ATTR amyloidosis and mainly includes hereditary ATTR (ATTRv) amyloidosis and wild-type ATTR (ATTRwt) amyloidosis. Until recently, ATTRv amyloidosis had been considered a disease in the field of neurology because neuropathic symptoms predominated in patients described in early ...
Haruki Koike, Takahiro Okumura, Toyoaki Murohara, Masahisa Katsuno   +3 more
openaire   +2 more sources

Transthyretin (TTR) Cardiac Amyloidosis [PDF]

Circulation, 2012
(Uploaded by Plazi for the Bat Literature Project) No abstract provided.
Frederick L, Ruberg, John L, Berk
openaire   +2 more sources

Hereditary cardiac amyloidosis associated with Pro24Ser transthyretin mutation: a case report

Journal of Medical Case Reports, 2018
Background Transthyretin amyloidosis is a systemic disorder caused by extracellular deposition of insoluble amyloid fibrils in peripheral and autonomic nerves, heart, kidney, gastrointestinal tract, and other organs.
Hiroyuki Yamamoto, Toru Hashimoto, Shunji Kawamura, Michiaki Hiroe, Taro Yamashita, Yukio Ando, Tomoki Yokochi   +6 more
doaj   +1 more source

Strong positive light chain immunostaining in a patient with transthyretin amyloidosis

Hematology, 2023
The two most common systemic amyloidosis types are immunoglobulin light chain (AL) and amyloid transthyretin (ATTR) amyloidosis, in which the precursor proteins responsible for amyloidosis are light chain and transthyretin, respectively.
Jiao Chen, Haifei Chen, Lingyun Zhou, Danbo Liu, Fang Du, Hongxian Xiang   +5 more
doaj   +1 more source