Results 11 to 20 of about 44,633 (211)
Management of transthyretin amyloidosis [PDF]
Swiss medical weekly, 2021 Transthyretin amyloidosis (ATTR amyloidosis) is a disease caused by deposition of transthyretin fibrils in organs and tissues, which causes their dysfunction. The clinical heterogeneity of ATTR amyloidosis and the variable presentation of symptoms at early disease stages, historically meant treatment delays. Diagnostic tools and therapy options of ATTR
Condoluci, Adalgisa +43 more
core +6 more sources
Clinical and Genotype Characteristics and Symptom Migration in Patients With Mixed Phenotype Transthyretin Amyloidosis from the Transthyretin Amyloidosis Outcomes Survey [PDF]
Cardiology and Therapy, 2023 Introduction Transthyretin amyloidosis (ATTR amyloidosis) is primarily associated with a cardiac or neurologic phenotype, but a mixed phenotype is increasingly described.
Juan González-Moreno +13 more
doaj +4 more sources
Systemic Transthyretin Amyloidosis Incidentally Diagnosed With Prostate Biopsy: A Case Report
IJU Case ReportsIntroduction The diagnosis of systemic transthyretin amyloidosis based on prostate biopsy is very rare, and we report this case with a literature review.
Michihide Nakamura +14 more
doaj +2 more sources
Guideline of transthyretin-related hereditary amyloidosis for clinicians [PDF]
Orphanet Journal of Rare Diseases, 2013 Transthyretin amyloidosis is a progressive and eventually fatal disease primarily characterized by sensory, motor, and autonomic neuropathy and/or cardiomyopathy.
Ando Yukio +11 more
doaj +3 more sources
Inotersen: new promise for the treatment of hereditary transthyretin amyloidosis [PDF]
Drug Design, Development and Therapy, 2019 Veena Mathew,1 Annabel K Wang1,2 1Department of Neurology, UCI ALS and Neuromuscular Center, University of California, Irvine, Orange, CA, USA; 2Neurology Section, Tibor Rubin VA Medical Center, Long Beach, CA, USA Abstract: Hereditary transthyretin ...
Mathew V, Wang AK
doaj +3 more sources
Hereditary transthyretin amyloidosis (ATTRv)
Current Problems in CardiologyHereditary transthyretin (TTR) amyloidosis (ATTRv amyloidosis) is a devastating disease characterized by broad range of clinical manifestations, including predominantly neurological, predominantly cardiac, and mixed phenotypes. This wide phenotypic variability hindered timely disease diagnosis and risk stratification in the past, especially in ...
Filippos Triposkiadis +8 more
openaire +4 more sources
Transthyretin amyloidosis [PDF]
Nursing, 2020 Abstract: Cardiac amyloidosis is a poorly understood cause of heart failure and is often undiagnosed. Recent advances in diagnostic testing and understanding of the disease have enhanced the ability of clinicians to detect this disease and provide patients with appropriate treatment.
Renáta Aiglová +3 more
openaire +3 more sources
Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy
New England Journal of MedicineTransthyretin amyloidosis with cardiomyopathy (ATTR-CM) is a progressive, fatal disease. Vutrisiran, a subcutaneously administered RNA interference therapeutic agent, inhibits the production of hepatic transthyretin.In this double-blind, randomized trial, we assigned patients with ATTR-CM in a 1:1 ratio to receive vutrisiran (25 mg) or placebo every 12
Marianna Fontana +36 more
openaire +5 more sources
Transthyretin Amyloidosis and the Kidney [PDF]
Clinical Journal of the American Society of Nephrology, 2012 Summary The amyloidoses are protein-misfolding disorders associated with progressive organ dysfunction. Immunoglobulin light chain is the most common, amyloid A the longest recognized, and transthyretin-associated amyloidosis (ATTR) the most frequent inherited systemic form.
Luísa, Lobato, Ana, Rocha
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Multidisciplinary Approaches for Transthyretin Amyloidosis [PDF]
Cardiology and Therapy, 2021 Amyloidosis caused by systemic deposition of transthyretin (TTR) is called ATTR amyloidosis and mainly includes hereditary ATTR (ATTRv) amyloidosis and wild-type ATTR (ATTRwt) amyloidosis. Until recently, ATTRv amyloidosis had been considered a disease in the field of neurology because neuropathic symptoms predominated in patients described in early ...
Haruki Koike +3 more
openaire +2 more sources