Results 121 to 130 of about 5,329 (284)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Alterações fisiológicas em praticantes do paraquedismo [PDF]
, 2013 TCC (Graduação) - Universidade Federal de Santa Catarina. Centro de Desportos. Curso de Graduação em Educação Física.Esportes considerados radicais são diferenciados por conter um alto componente de risco e aventura, desencadeando assim elevados níveis
Ribeiro, Felix Duenha
core
An existence theorem for group divisible 3-designs of large order
, 2011 In this paper we establish an asymptotic existence result for group divisible 3-designs of large order. Let k and u be positive integers, 3⩽k⩽u. Then there exists an integer m0=m0(k,u) such that there exists a group divisible 3-design of group type mu ...
Hedvig Mohácsy, Mohácsy, Hedvig
core +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Validação de um dispositivo de interrupção súbita da furação com brocas helicoidais para análise da raiz de cavaco [PDF]
, 2013 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Mecânica, Florianópolis, 2013.A furação com brocas helicoidais é um dos processos de usinagem mais empregados pela indústria ...
Moreno, Diego Alejandro Neira
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Revisiting Key Predistribution Using Transversal Designs for a Grid-Based Deployment Scheme
International Journal of Distributed Sensor Networks, 2009 Sushmita Ruj, Bimal Roy
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Creating Entangled Logical Qubits in the Heavy-Hex Lattice with Topological Codes
PRX QuantumDesigns for quantum error correction depend strongly on the connectivity of the qubits. For solid-state qubits, the most straightforward approach is to have connectivity constrained to a planar graph.
Bence Hetényi, James R. Wootton
doaj +1 more source