Results 101 to 110 of about 55,578 (283)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Potential and challenges of service-learning as an inclusive methodology for competency development in students with SEN

Discover Education
Service-learning (SL) is a pedagogical methodology that combines academic learning with community service, promoting inclusion and the development of transversal skills.
Miriam Catalina González-Afonso, Carmen de Los Ángeles Perdomo-López, David Pérez-Jorge   +2 more
doaj   +1 more source

Tri-/Quad-/Quint-Band Bandpass Filters Based on Transversal Embedded Asymmetrical Square-Ring Resonator

IEEE Access
This paper presents a series design method for tri-/quad-/and quint band bandpass filter (BPF) with multiple transmission zeros (TZs) based on an embedded asymmetrical square-ring resonator (ASRR).
Xiaohan Wan, Zhengzhen Jin, Yifan Wang, Guoxin Xu, Lei Zhang, Yang Xiong, Litian Wang   +6 more
doaj   +1 more source

Applying Emmert’s Law to the Poggendorff Illusion

Frontiers in Human Neuroscience, 2015
The Poggendorff illusion was approached with a novel perspective, that of applying Emmert’s Law to the situation. The extensities between the verticals and the transversals happen to be absolutely equal in retinal image size, whereas the registered ...
Umur eTalasli, Asli Bahar Inan
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Asymmetric Substrate Integrated Waveguide Leaky Wave Antenna with Open Stop Band Suppression and Radiation Efficiency Equalization Through Broadside [PDF]

Radioengineering, 2018
A planar asymmetric substrate integrated wave¬guide leaky wave antenna is proposed with open stop band suppression and radiation efficiency equalization through broadside for the Ku-band. The stop-band behavior exhib¬ited at broadside in the 1-D periodic
R. Agrawal, P. Belwal, S. C. Gupta
doaj  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Application of Support Vector Machine in Designing Theo Jansen Linkages

Applied Sciences, 2019
Theo Jansen linkage is an appealing mechanism to implement a bio-inspired motion for a legged robot. The oval orbit that is generated by the Theo Jansen linkage, possessing a transversal axis longer than a lateral axis, achieves energy efficient walking ...
Min-Chan Hwang, Chiou-Jye Huang, Feifei Liu   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source