Results 81 to 90 of about 55,578 (283)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Joining by forming technology for thermal applications: A case study of finned tube heat exchanger
Case Studies in Thermal EngineeringHeat exchangers are essential for various thermal applications, and their performance could be improved by optimization of layout/operating conditions or materials.
Riccardo Saltarelli +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Combinatorial designs with two singular values II. Partial geometric designs. [PDF]
In this and an earlier paper [17] we study combinatorial designs whose incidence matrix has two distinct singular values.These generalize (v, k, ë) designs, and include uniform multiplicative designs and partial geometric designs.Here we study the latter,
Dam, E.R. van, Spence, E.
core +4 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
In-Vehicle Safety System Performance Depending on the Quality of Road Markings
Promet (Zagreb), 2007 During driving one of the basic tasks of the driver is to followthe traffic route in such a way as not to endanger in the processother traffic participants.
Anđelko Ščukanec +2 more
doaj +1 more source
Design of FIR digital filters for pulse shaping and channel equalization using time-domain optimization [PDF]
Three algorithms are developed for designing finite impulse response digital filters to be used for pulse shaping and channel equalization. The first is the Minimax algorithm which uses linear programming to design a frequency-sampling filter with a ...
Houts, R. C., Vaughn, G. L.
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Revista Latino-Americana de Enfermagem, 2015 Objective:to identify and analyze the evidence available regarding evaluation of burden and quality of life of mothers who are caregivers for children and adolescents with chronic illnesses.Method:an integrative review, undertaken in the electronic ...
Eliza Cristina Macedo +3 more
doaj +1 more source
Frame difference families and resolvable balanced incomplete block designs
, 2018 Frame difference families, which can be obtained via a careful use of cyclotomic conditions attached to strong difference families, play an important role in direct constructions for resolvable balanced incomplete block designs.
Costa, Simone, Feng, Tao, Wang, Xiaomiao
core +1 more source