CSAKD: Determining Absolute Ligand Affinities From 19F NMR Chemical Shift Anisotropy
Affinity determination is crucial in drug discovery, yet remains difficult for weakly binding fragments. We introduce chemical shift anisotropy KD$K_{\text{D}}$ (CSAKD) by 19F$^{19}{\rm F}$ NMR relaxation experiments, a titration‐free method that requires no isotopic labeling.
Simon H. Rüdisser +2 more
wiley +2 more sources
Biomechanical risk factors for tibial plateau fracture following Oxford unicompartmental knee arthroplasty: a finite element analysis under gait loading. [PDF]
Ji J +8 more
europepmc +1 more source
Evolution of P‐wave Anisotropy as an Indicator of Pre‐failure Deformation in Shale
Abstract Understanding the multiscale mechanical behavior of clay‐rich rocks is critical for assessing fault reactivation and the long‐term integrity of underground waste repositories. This study investigates the evolution of microdeformation in Tournemire's shale samples under compressive stress by integrating high‐resolution imaging (from an ...
Matthieu Lusseyran +5 more
wiley +1 more source
Experimental investigation of mechanical properties in cryogenically damaged shale. [PDF]
Zheng X +6 more
europepmc +1 more source
Inverse Drexhage Effect in Epsilon‐Near‐Zero Substrates
Radiative emission of dipoles near substrates is shown to reverse between (a) perfect electric conductors and (b) epsilon‐near‐zero (ENZ) media. The schematic highlights switch from vertical to horizontal dipole dominance, governed by interference with image dipoles, leading to directional emission into the upper half‐space and enabling new strategies ...
Sandeep Kumar Chamoli, Mohamed ElKabbash
wiley +1 more source
Evaluation of collapsible deformation of foundation under rectangular load based on the improved binary medium model. [PDF]
Abbas N +6 more
europepmc +1 more source
Mechanochemical modeling of exercise-induced skeletal muscle hypertrophy
Devold IS, Rognes ME, Rangamani P.
europepmc +1 more source
Study on constitutive model of marine soft soil based on disturbed state concept. [PDF]
Zhang H +6 more
europepmc +1 more source
Full-field noise-correlation elastography for in-plane mechanical anisotropy imaging. [PDF]
Marmin A +5 more
europepmc +1 more source

