Results 91 to 100 of about 7,161 (183)

Lysine-Specific Demethylase 1 Inhibitors: A Comprehensive Review Utilizing Computer-Aided Drug Design Technologies

Molecules
Lysine-specific demethylase 1 (LSD1/KDM1A) has emerged as a promising therapeutic target for treating various cancers (such as breast cancer, liver cancer, etc.) and other diseases (blood diseases, cardiovascular diseases, etc.), owing to its observed ...
Di Han, Jiarui Lu, Baoyi Fan, Wenfeng Lu, Yiwei Xue, Meiting Wang, Taigang Liu, Shaoli Cui, Qinghe Gao, Yingchao Duan, Yongtao Xu   +10 more
doaj   +1 more source

Molecular aspects of monoamine oxidase B [PDF]

, 2016
Monoamine oxidases (MAO) influence the monoamine levels in brain by virtue of their role in neurotransmitter breakdown. MAO B is the predominant form in glial cells and in platelets.
Ramsay, Rona Ruth
core   +1 more source

Electronic Health Record Availability and Anxiety Treatment in Office Based Practices [PDF]

, 2016
Objective: This study compared the probability of receiving anxiety treatment during a physician visit to primary care practices with and without an electronic health record (EHR).
Cook, Robert L., Harle, Christopher A., Harman, Jeffrey S., Mills, Jon   +3 more
core   +1 more source

Helicobacter pylori regulates iNOS promoter by histone modifications in human gastric epithelial cells. [R. Pero* corresponding author] [PDF]

, 2012
Inducible nitric oxide synthase (iNOS) expression is altered in gastrointestinal diseases. Helicobacter pylori (Hp) infection may have a critical role in iNOS disregulation.
AT Franco, BM Turner, C Chan, C Magerl, CC Wang, D Fukumura, DM Schmidt, E Metzger, F Fuks, F Perri, Francesca Lembo, G Le’Negrate, H Kolb, H Suzuki, J Parsonnet, JC Atherton, JM Kim, JW Lim, K Komoto, K Uno, KJ Livak, LJ Doorn van, Lorenzo Chiariotti, M Erkisi, M Gerhard, M Romano, M Yang, MA Hamon, MF Maat de, MG Lee, MG Lee, P Lejeune, PT Georgel, Q Zheng, R Pero, RA Aras, Raffaela Pero, RH Liu, RM Peek, S Fu, SF Kim, Silvia Peluso, Simona Keller, SK Pathak, SL Berger, T Angrisano, T Jenuwein, T Kouzarides, T Maekita, T Motoyama, T Watanabe, Tiziana Angrisano, TL Cover, WC You, WG Deng, Y Naito, Y Naito, Y Saito, YJ Chang, YJ Shi   +59 more
core   +1 more source

La sexualité de la personne âgée et les médicaments [PDF]

, 1980
De nombreux médicaments ont été mentionnés comme ayant des effets adverses sur les fonctions sexuelles. L'interférence avec l'éjaculation chez l'homme, l'échec à atteindre l'orgasme chez la femme, la libido diminuée peuvent survenir avec n'importe quel ...
Barbeau, Gilles
core   +1 more source

Levothyroxine effects on depressive symptoms and limbic glucose metabolism in bipolar disorder: a randomized, placebo-controlled positron emission tomography study. [PDF]

, 2016
Adding supraphysiologic doses of levothyroxine (L-T4) to standard treatment for bipolar depression shows promise, but the mechanisms underlying clinical improvement are unknown.
Adli, M, Bauer, M, Berman, S, Hellemann, GS, London, ED, Pilhatsch, M, Plotkin, M, Schlagenhauf, F, Stamm, T, Whybrow, PC   +9 more
core  

Dynamics of Cell Fate Decisions during Chemically Induced Multi‐Lineage Trans‐Differentiation at Single‐Cell Level

Advanced Science
Cell trans‐differentiation offers a powerful means to manipulate cell identities. By exposing cells to a combination of small molecules (SMs), cell trans‐differentiation can be induced in a simple and cost‐effective manner. However, a comprehensive atlas
Weigao E, Lijiang Fei, Jingjing Wang, Xinru Wang, Renying Wang, Xueyi Wang, Peijing Zhang, Jianhui Chen, Junqing Wu, Mengmeng Jiang, Daosheng Huang, Danmei Jia, Guoji Guo, Xiaoping Han   +13 more
doaj   +1 more source

MAO inhibitors for treatment-resistant depression: Bringing an updated perspective on pioneering drugs

Pharmacological Research
In the 1950s, monoamine oxidase inhibitors transformed the pharmacological treatment of mental disorders as the first class of antidepressant drugs.
Larissa Junkes, Laiana A. Quagliato, Jose C. Appolinario, Richard I. Shader, Antonio E. Nardi   +4 more
doaj   +1 more source

Identification and Evaluation of Olive Phenolics in the Context of Amine Oxidase Enzyme Inhibition and Depression: In Silico Modelling and In Vitro Validation

Molecules
The Mediterranean diet well known for its beneficial health effects, including mood enhancement, is characterised by the relatively high consumption of extra virgin olive oil (EVOO), which is rich in bioactive phenolic compounds.
Tom C. Karagiannis, Katherine Ververis, Julia J. Liang, Eleni Pitsillou, Siyao Liu, Sarah M. Bresnehan, Vivian Xu, Stevano J. Wijoyo, Xiaofei Duan, Ken Ng, Andrew Hung, Erik Goebel, Assam El-Osta   +12 more
doaj   +1 more source

Domperidone for Drug-Induced Orthostatic Hypotension-A Review [PDF]

, 2011
Drug-induced orthostatic hypotension (OH) is a common side effect of heterocyclic and MAOI antidepressant medications. It usually does not respond to conservative treatment and drug treatments with mineralocorticoids or central dopaminergic antagonists ...
Lam, M.D., F.R.C.P.(C), Raymond W., McDonald, M.D., Daniel E.   +1 more
core   +1 more source